Regulation of Promoter Proximal Pausing of RNA Polymerase II in Metazoans

Roberta Dollinger, David S. Gilmour

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations


Regulation of transcription is a tightly choreographed process. The establishment of RNA polymerase II promoter proximal pausing soon after transcription initiation and the release of Pol II into productive elongation are key regulatory processes that occur in early elongation. We describe the techniques and tools that have become available for the study of promoter proximal pausing and their utility for future experiments. We then provide an overview of the factors and interactions that govern a multipartite pausing process and address emerging questions surrounding the mechanism of RNA polymerase II's subsequent advancement into the gene body. Finally, we address remaining controversies and future areas of study.

Original languageEnglish (US)
Article number166897
JournalJournal of Molecular Biology
Issue number14
StatePublished - Jul 9 2021

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Molecular Biology


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