Regulation of T-cell responses and disease by Tec kinase Itk

Avery August, Melanie J. Ragin

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations


Itk is a member of the Tec family tyrosine kinases involved in T-cell receptor signaling. The authors review the background and most recent findings of the role of Itk T-cell activation and development of αβ T cells. They also discuss the role of Itk in development of nonconventional T cells, including CD8 + innate memory phenotype T cells, different γ δ T-cell populations, and invariant NKT cells. They close by reviewing the regulation of T helper differentiation and cytokine secretion, the immune response to infectious disease, and diseases such as allergic asthma and atopic dermatitis by Itk.

Original languageEnglish (US)
Pages (from-to)155-165
Number of pages11
JournalInternational Reviews of Immunology
Issue number2
StatePublished - Apr 2012

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology


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