TY - JOUR
T1 - Regulation of T-cell responses and disease by Tec kinase Itk
AU - August, Avery
AU - Ragin, Melanie J.
N1 - Funding Information:
Accepted 20 February 2012. We thank members of the August lab for discussions. This work was supported by grants from the National Institutes of Health (AI051626, AI065566 and AI073955 to AA) and the Department of Education (CFDA #84.382G to MJR and Anand Yanav). The authors have no conflicting financial interests.
PY - 2012/4
Y1 - 2012/4
N2 - Itk is a member of the Tec family tyrosine kinases involved in T-cell receptor signaling. The authors review the background and most recent findings of the role of Itk T-cell activation and development of αβ T cells. They also discuss the role of Itk in development of nonconventional T cells, including CD8 + innate memory phenotype T cells, different γ δ T-cell populations, and invariant NKT cells. They close by reviewing the regulation of T helper differentiation and cytokine secretion, the immune response to infectious disease, and diseases such as allergic asthma and atopic dermatitis by Itk.
AB - Itk is a member of the Tec family tyrosine kinases involved in T-cell receptor signaling. The authors review the background and most recent findings of the role of Itk T-cell activation and development of αβ T cells. They also discuss the role of Itk in development of nonconventional T cells, including CD8 + innate memory phenotype T cells, different γ δ T-cell populations, and invariant NKT cells. They close by reviewing the regulation of T helper differentiation and cytokine secretion, the immune response to infectious disease, and diseases such as allergic asthma and atopic dermatitis by Itk.
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U2 - 10.3109/08830185.2012.668981
DO - 10.3109/08830185.2012.668981
M3 - Review article
C2 - 22449075
AN - SCOPUS:84860461389
SN - 0883-0185
VL - 31
SP - 155
EP - 165
JO - International Reviews of Immunology
JF - International Reviews of Immunology
IS - 2
ER -