@article{a1976316d5d84400a646d1f1a03fb99a,
title = "Regulatory mechanisms mediated by peroxisome proliferator-activated receptor-β/δ in skin cancer",
abstract = "Considerable progress has been made during the past 20 years towards elucidating the role of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) in skin cancer. In 1999, the original notion that PPARβ/δ was involved with epithelial cell function was postulated based on a correlation between PPARβ/δ expression and the induction of messenger RNAs encoding proteins that mediate terminal differentiation in keratinocytes. Subsequent studies definitively revealed that PPARβ/δ could induce terminal differentiation and inhibit proliferation of keratinocytes. Molecular mechanisms have since been discovered to explain how this nuclear receptor can be targeted for preventing and treating skin cancer. This includes the regulation of terminal differentiation, mitotic signaling, endoplasmic reticulum stress, and cellular senescence. Interestingly, the effects of activating PPARβ/δ can preferentially target keratinocytes with genetic mutations associated with skin cancer. This review provides the history and current understanding of how PPARβ/δ can be targeted for both nonmelanoma skin cancer and melanoma and postulates how future approaches that modulate PPARβ/δ signaling may be developed for the prevention and treatment of these diseases.",
author = "Peters, {Jeffrey M.} and Kim, {Dae J.} and Bility, {Moses T.} and Borland, {Michael G.} and Bokai Zhu and Gonzalez, {Frank J.}",
note = "Funding Information: This study supported in part by the National Institutes of Health (CA124533, CA140369, J. M. P.), the USDA National Institute of Food and Federal Appropriations under Project PEN04607 and Accession number 1009993 (J. M. P.), the Pennsylvania Department of Health using Tobacco C.U.R.E. Funds (J.M.P). The Department specifically disclaims responsibility for any analyses, interpretations or conclusions. This study was also supported by a National Science Foundation Graduate Research Fellowship, Bloomsburg University (BU) Academic Enhancement Funds (M. G. B.), a BU Research & Scholarship Grant (M. G. B.), and a BU Margin of Excellence Grant (M. G. B.), National Institute of Environmental Health (ES022250, D.J.K.), National Institutes of Health (OD024789, AI135412, M. T. B.), American Diabetes Association grant #1 to 18-JDF-025 (B. K.). Funding Information: National Institute of Allergy and Infectious Diseases, Grant/Award Number: AI135412; National Institutes of Health, Grant/Award Number: CA124533, CA140369; USDA National Institute of Food and Federal Appropriations; Pennsylvania Department of Health using Tobacco C.U.R.E. Funds; National Science Foundation Graduate Research Fellowship; Bloomsburg University (BU) Academic Enhancement Funds; BU Research & Scholarship Grant; National Institute of Environmental Health, Grant/Award Number: ES022250; National Institutes of Health, Grant/Award Number: OD024789, AI135412; American Diabetes Association #1 to 18‐JDF‐025 Funding Information: This study supported in part by the National Institutes of Health (CA124533, CA140369, J. M. P.), the USDA National Institute of Food and Federal Appropriations under Project PEN04607 and Accession number 1009993 (J. M. P.), the Pennsylvania Department of Health using Tobacco C.U.R.E. Funds (J.M.P). The Department specifically disclaims responsibility for any analyses, interpretations or conclusions. This study was also supported by a National Science Foundation Graduate Research Fellowship, Bloomsburg University (BU) Academic Enhancement Funds (M. G. B.), a BU Research & Scholarship Grant (M. G. B.), and a BU Margin of Excellence Grant (M. G. B.), National Institute of Environmental Health (ES022250, D.J.K.), National Institutes of Health (OD024789, AI135412, M. T. B.), American Diabetes Association grant #1 to 18‐JDF‐025 (B. K.). Publisher Copyright: {\textcopyright} 2019 Wiley Periodicals, Inc.",
year = "2019",
month = sep,
doi = "10.1002/mc.23033",
language = "English (US)",
volume = "58",
pages = "1612--1622",
journal = "Molecular Carcinogenesis",
issn = "0899-1987",
publisher = "Wiley-Liss Inc.",
number = "9",
}
