Regulatory mechanisms triggered by enzyme interactions with lipid membrane surfaces

Research output: Contribution to journalReview articlepeer-review

Abstract

Recruitment of enzymes to intracellular membranes often modulates their catalytic activity, which can be important in cell signaling and membrane trafficking. Thus, re-localization is not only important for these enzymes to gain access to their substrates, but membrane interactions often allosterically regulate enzyme function by inducing conformational changes across different time and amplitude scales. Recent structural, biophysical and computational studies have revealed how key enzymes interact with lipid membrane surfaces, and how this membrane binding regulates protein structure and function. This review summarizes the recent progress in understanding regulatory mechanisms involved in enzyme-membrane interactions.

Original languageEnglish (US)
Article number1306483
JournalFrontiers in Molecular Biosciences
Volume10
DOIs
StatePublished - 2023

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)

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