Regulatory T cells versus Th17: Differentiation of Th17 versus treg, are they mutually exclusive?

Song Guo Zheng

doi:10.1007/978-3-0348-0522-3_6

Regulatory T cells versus Th17: Differentiation of Th17 versus treg, are they mutually exclusive?

Song Guo Zheng

Department of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

Naive CD4⁺ cells differentiate into T helper (Th1, Th2, Th9, Th17) and regulatory T (Treg) cells to execute their immunologic function. Whereas TGF-B suppresses Th1 and Th2 cell differentiation, this cytokine promotes Th9, Th17, and Foxp3⁺ regulatory T cells depending upon the existence of other cytokines. IL-6 promotes Th17 but suppresses regulatory T cell differentiation. Moreover, natural but not TGF-B-induced regulatory T cells convert into Th17 cells in the inflammatory milieu. This chapter discusses the updates of these cell differentiation and conversion, as well as underlying mechanisms.

Original language	English (US)
Title of host publication	IL-17, IL-22 and Their Producing Cells
Subtitle of host publication	Role in Inflammation and Autoimmunity
Publisher	Springer Basel
Pages	91-107
Number of pages	17
ISBN (Electronic)	9783034805223
ISBN (Print)	9783034805216
DOIs	https://doi.org/10.1007/978-3-0348-0522-3_6
State	Published - Jan 1 2013

All Science Journal Classification (ASJC) codes

Medicine(all)
Immunology and Microbiology(all)

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10.1007/978-3-0348-0522-3_6

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abstract = "Naive CD4+ cells differentiate into T helper (Th1, Th2, Th9, Th17) and regulatory T (Treg) cells to execute their immunologic function. Whereas TGF-B suppresses Th1 and Th2 cell differentiation, this cytokine promotes Th9, Th17, and Foxp3+ regulatory T cells depending upon the existence of other cytokines. IL-6 promotes Th17 but suppresses regulatory T cell differentiation. Moreover, natural but not TGF-B-induced regulatory T cells convert into Th17 cells in the inflammatory milieu. This chapter discusses the updates of these cell differentiation and conversion, as well as underlying mechanisms.",

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AB - Naive CD4+ cells differentiate into T helper (Th1, Th2, Th9, Th17) and regulatory T (Treg) cells to execute their immunologic function. Whereas TGF-B suppresses Th1 and Th2 cell differentiation, this cytokine promotes Th9, Th17, and Foxp3+ regulatory T cells depending upon the existence of other cytokines. IL-6 promotes Th17 but suppresses regulatory T cell differentiation. Moreover, natural but not TGF-B-induced regulatory T cells convert into Th17 cells in the inflammatory milieu. This chapter discusses the updates of these cell differentiation and conversion, as well as underlying mechanisms.

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Regulatory T cells versus Th17: Differentiation of Th17 versus treg, are they mutually exclusive?

Abstract

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