Abstract
Naive CD4+ cells differentiate into T helper (Th1, Th2, Th9, Th17) and regulatory T (Treg) cells to execute their immunologic function. Whereas TGF-B suppresses Th1 and Th2 cell differentiation, this cytokine promotes Th9, Th17, and Foxp3+ regulatory T cells depending upon the existence of other cytokines. IL-6 promotes Th17 but suppresses regulatory T cell differentiation. Moreover, natural but not TGF-B-induced regulatory T cells convert into Th17 cells in the inflammatory milieu. This chapter discusses the updates of these cell differentiation and conversion, as well as underlying mechanisms.
Original language | English (US) |
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Title of host publication | IL-17, IL-22 and Their Producing Cells |
Subtitle of host publication | Role in Inflammation and Autoimmunity |
Publisher | Springer Basel |
Pages | 91-107 |
Number of pages | 17 |
ISBN (Electronic) | 9783034805223 |
ISBN (Print) | 9783034805216 |
DOIs | |
State | Published - Jan 1 2013 |
All Science Journal Classification (ASJC) codes
- General Medicine
- General Immunology and Microbiology