Relationship of gliomas to the ventricular walls

Kaveh Barami, Andrew E. Sloan, Amyn Rojiani, Michael J. Schell, Aileen Staller, Steven Brem

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


The role of neural stem cells in gliomagenesis remains controversial. The aim of this study was to determine the anatomic relationship of human gliomas to the lining of the ventricular walls, known as the subventricular zone, an area replete with neural stem cells. We performed a retrospective radiographic analysis of 100 consecutive patients with gliomas and sought to determine the relationship of the lesions to the ventricular walls as seen on their MRI scans. Our results indicated that in 93% of cases the lesions contacted at least one region of the lateral ventricular wall. Contact with the ventricular wall was independent of the glioma size or mass effect. These findings were correlated to cytoarchitectural studies of the human subventricular zone. Our findings lend further support that there is an intimate association between gliomas and the subventricular zone.

Original languageEnglish (US)
Pages (from-to)195-201
Number of pages7
JournalJournal of Clinical Neuroscience
Issue number2
StatePublished - Feb 2009

All Science Journal Classification (ASJC) codes

  • Surgery
  • Neurology
  • Clinical Neurology
  • Physiology (medical)


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