TY - JOUR
T1 - Relationship of serum levels of individual PCB, dioxin, and furan congeners and DDE with Great Lakes sport-caught fish consumption
AU - Turyk, Mary
AU - Anderson, Henry A.
AU - Hanrahan, Lawrence P.
AU - Falk, Claire
AU - Steenport, Dyan N.
AU - Needham, Larry L.
AU - Patterson, Donald G.
AU - Freels, Sally
AU - Persky, Victoria
AU - Boddy, James
AU - Budd, Marvin
AU - Burkett, Mandy
AU - Fiore, Beth
AU - Humphrey, Harold E.B.
AU - Johnson, Robert
AU - Lee, Grace
AU - Monaghan, Susan
AU - Reed, Daniel
AU - Shelley, Tracey
AU - Sonzogni, William
AU - Steele, Greg
AU - Wright, Dollis
N1 - Funding Information:
This research was funded by the Agency for Toxic Substances and Disease Registry, Atlanta, GA, USA, Grant No. H75/ATH598322. This study was conducted in accordance with national and institutional guidelines for the protection of human subjects. Prior to initiation of this study protocol, it was reviewed and approved by the University of Wisconsin–Madison Medical School Human Subjects Committee and the University of Illinois–Chicago Institutional Review Board. Informed consent was obtained from each subject prior to participation.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2006/2
Y1 - 2006/2
N2 - Great Lakes (GL) sport fish consumption is a potential route of exposure for environmentally persistent organochlorine contaminants, which may have human health effects. In this report, relationships are explored among individual congeners in a large cohort of frequent and infrequent GL sport fish consumers. Blood samples were obtained in 1993-1995 and analyzed for 1,1-bis(4- chlorophenyl)-2,2-dichloroethene (DDE) and for 62 noncoplanar polychlorinated biphenyls (PCBs), 4 coplanar PCBs, 8 polychlorinated dibenzo-p-dioxin (dioxin), and10 dibenzofuran (furan) congeners. All GL fish eaters and referents had detectable levels of DDE, total noncoplanar PCBs, total coplanar PCBs, total dioxins, and total furans. Noncoplanar PCBs were higher in GL sport fish consumers than in a referent population from the same geographic area, were associated with GL sport-caught fish (GLSCF) consumption, and varied significantly by Great Lake. DDE, lower chlorinated dioxin and furan toxic equivalents (TEQs), and coplanar PCB TEQs were positively associated with noncoplanar PCBs but were not associated with GL sport fish consumption independent of PCB level. Highly chlorinated dioxin and furan congener TEQs were not significantly associated with noncoplanar PCBs or GL sport fish consumption, suggesting that participants were acquiring some of these TEQs from a source other than GLSCF. In epidemiologic studies, it may be important to include populations with higher organochlorine exposures as well as background exposures and to consider the effects of individual congeners or mixtures of congeners on health outcomes.
AB - Great Lakes (GL) sport fish consumption is a potential route of exposure for environmentally persistent organochlorine contaminants, which may have human health effects. In this report, relationships are explored among individual congeners in a large cohort of frequent and infrequent GL sport fish consumers. Blood samples were obtained in 1993-1995 and analyzed for 1,1-bis(4- chlorophenyl)-2,2-dichloroethene (DDE) and for 62 noncoplanar polychlorinated biphenyls (PCBs), 4 coplanar PCBs, 8 polychlorinated dibenzo-p-dioxin (dioxin), and10 dibenzofuran (furan) congeners. All GL fish eaters and referents had detectable levels of DDE, total noncoplanar PCBs, total coplanar PCBs, total dioxins, and total furans. Noncoplanar PCBs were higher in GL sport fish consumers than in a referent population from the same geographic area, were associated with GL sport-caught fish (GLSCF) consumption, and varied significantly by Great Lake. DDE, lower chlorinated dioxin and furan toxic equivalents (TEQs), and coplanar PCB TEQs were positively associated with noncoplanar PCBs but were not associated with GL sport fish consumption independent of PCB level. Highly chlorinated dioxin and furan congener TEQs were not significantly associated with noncoplanar PCBs or GL sport fish consumption, suggesting that participants were acquiring some of these TEQs from a source other than GLSCF. In epidemiologic studies, it may be important to include populations with higher organochlorine exposures as well as background exposures and to consider the effects of individual congeners or mixtures of congeners on health outcomes.
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U2 - 10.1016/j.envres.2005.04.005
DO - 10.1016/j.envres.2005.04.005
M3 - Article
C2 - 15979066
AN - SCOPUS:31544467543
SN - 0013-9351
VL - 100
SP - 173
EP - 183
JO - Environmental Research
JF - Environmental Research
IS - 2
ER -
