Remdesivir for the Prevention of Invasive Mechanical Ventilation or Death in Coronavirus Disease 2019 (COVID-19): A Post Hoc Analysis of the Adaptive COVID-19 Treatment Trial-1 Cohort Data

Catharine I. Paules; Shannon K. Gallagher; Rekha R. Rapaka; Richard T. Davey; Sarah B. Doernberg; Robert Grossberg; Noreen A. Hynes; Philip O. Ponce; William R. Short; Jocelyn Voell; Jing Wang; Otto O. Yang; Cameron R. Wolfe; David C. Lye; Lori E. Dodd; Constance A. Benson

doi:10.1093/cid/ciab695

Remdesivir for the Prevention of Invasive Mechanical Ventilation or Death in Coronavirus Disease 2019 (COVID-19): A Post Hoc Analysis of the Adaptive COVID-19 Treatment Trial-1 Cohort Data

Catharine I. Paules, Shannon K. Gallagher, Rekha R. Rapaka, Richard T. Davey, Sarah B. Doernberg, Robert Grossberg, Noreen A. Hynes, Philip O. Ponce, William R. Short, Jocelyn Voell, Jing Wang, Otto O. Yang, Cameron R. Wolfe, David C. Lye, Lori E. Dodd, Constance A. Benson

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11 Scopus citations

Abstract

This post hoc analysis of the Adaptive Coronavirus Disease 2019 (COVID-19) Treatment Trial-1 (ACTT-1) shows a treatment effect of remdesivir (RDV) on progression to invasive mechanical ventilation (IMV) or death. Additionally, we create a risk profile that better predicts progression than baseline oxygen requirement alone. The highest risk group derives the greatest treatment effect from RDV.

Original language	English (US)
Pages (from-to)	1260-1264
Number of pages	5
Journal	Clinical Infectious Diseases
Volume	74
Issue number	7
DOIs	https://doi.org/10.1093/cid/ciab695
State	Published - Apr 1 2022

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Infectious Diseases

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10.1093/cid/ciab695

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Paules, C. I., Gallagher, S. K., Rapaka, R. R., Davey, R. T., Doernberg, S. B., Grossberg, R., Hynes, N. A., Ponce, P. O., Short, W. R., Voell, J., Wang, J., Yang, O. O., Wolfe, C. R., Lye, D. C., Dodd, L. E., & Benson, C. A. (2022). Remdesivir for the Prevention of Invasive Mechanical Ventilation or Death in Coronavirus Disease 2019 (COVID-19): A Post Hoc Analysis of the Adaptive COVID-19 Treatment Trial-1 Cohort Data. Clinical Infectious Diseases, 74(7), 1260-1264. https://doi.org/10.1093/cid/ciab695

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title = "Remdesivir for the Prevention of Invasive Mechanical Ventilation or Death in Coronavirus Disease 2019 (COVID-19): A Post Hoc Analysis of the Adaptive COVID-19 Treatment Trial-1 Cohort Data",

abstract = "This post hoc analysis of the Adaptive Coronavirus Disease 2019 (COVID-19) Treatment Trial-1 (ACTT-1) shows a treatment effect of remdesivir (RDV) on progression to invasive mechanical ventilation (IMV) or death. Additionally, we create a risk profile that better predicts progression than baseline oxygen requirement alone. The highest risk group derives the greatest treatment effect from RDV.",

author = "Paules, {Catharine I.} and Gallagher, {Shannon K.} and Rapaka, {Rekha R.} and Davey, {Richard T.} and Doernberg, {Sarah B.} and Robert Grossberg and Hynes, {Noreen A.} and Ponce, {Philip O.} and Short, {William R.} and Jocelyn Voell and Jing Wang and Yang, {Otto O.} and Wolfe, {Cameron R.} and Lye, {David C.} and Dodd, {Lori E.} and Benson, {Constance A.}",

year = "2022",

month = apr,

day = "1",

doi = "10.1093/cid/ciab695",

language = "English (US)",

volume = "74",

pages = "1260--1264",

journal = "Clinical Infectious Diseases",

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Paules, CI, Gallagher, SK, Rapaka, RR, Davey, RT, Doernberg, SB, Grossberg, R, Hynes, NA, Ponce, PO, Short, WR, Voell, J, Wang, J, Yang, OO, Wolfe, CR, Lye, DC, Dodd, LE & Benson, CA 2022, 'Remdesivir for the Prevention of Invasive Mechanical Ventilation or Death in Coronavirus Disease 2019 (COVID-19): A Post Hoc Analysis of the Adaptive COVID-19 Treatment Trial-1 Cohort Data', Clinical Infectious Diseases, vol. 74, no. 7, pp. 1260-1264. https://doi.org/10.1093/cid/ciab695

Remdesivir for the Prevention of Invasive Mechanical Ventilation or Death in Coronavirus Disease 2019 (COVID-19): A Post Hoc Analysis of the Adaptive COVID-19 Treatment Trial-1 Cohort Data. / Paules, Catharine I.; Gallagher, Shannon K.; Rapaka, Rekha R. et al.
In: Clinical Infectious Diseases, Vol. 74, No. 7, 01.04.2022, p. 1260-1264.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Remdesivir for the Prevention of Invasive Mechanical Ventilation or Death in Coronavirus Disease 2019 (COVID-19)

T2 - A Post Hoc Analysis of the Adaptive COVID-19 Treatment Trial-1 Cohort Data

AU - Paules, Catharine I.

AU - Gallagher, Shannon K.

AU - Rapaka, Rekha R.

AU - Davey, Richard T.

AU - Doernberg, Sarah B.

AU - Grossberg, Robert

AU - Hynes, Noreen A.

AU - Ponce, Philip O.

AU - Short, William R.

AU - Voell, Jocelyn

AU - Wang, Jing

AU - Yang, Otto O.

AU - Wolfe, Cameron R.

AU - Lye, David C.

AU - Dodd, Lori E.

AU - Benson, Constance A.

PY - 2022/4/1

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AB - This post hoc analysis of the Adaptive Coronavirus Disease 2019 (COVID-19) Treatment Trial-1 (ACTT-1) shows a treatment effect of remdesivir (RDV) on progression to invasive mechanical ventilation (IMV) or death. Additionally, we create a risk profile that better predicts progression than baseline oxygen requirement alone. The highest risk group derives the greatest treatment effect from RDV.

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Remdesivir for the Prevention of Invasive Mechanical Ventilation or Death in Coronavirus Disease 2019 (COVID-19): A Post Hoc Analysis of the Adaptive COVID-19 Treatment Trial-1 Cohort Data

Abstract

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