Remdesivir-Induced Bradycardia

Sai Gautham Kanagala; Hardeep Dholiya; Poonam Jhajj; Meet A. Patel; Vasu Gupta; Sachin Gupta; Shiau Ing Wu; Rohit Jain

doi:10.14423/SMJ.0000000000001519

Remdesivir-Induced Bradycardia

Sai Gautham Kanagala, Hardeep Dholiya, Poonam Jhajj, Meet A. Patel, Vasu Gupta, Sachin Gupta, Shiau Ing Wu, Rohit Jain

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Remdesivir, a viral RNA-dependent RNA polymerase inhibitor, found extensive use in coronavirus disease 2019-infected patients because it curbs the viral load expansion. Among patients hospitalized as a result of lower respiratory tract infection, remdesivir proved to improve recovery time; however, remdesivir also can induce significant cytotoxic effects on cardiac myocytes. In this narrative review, we discuss the pathophysiological mechanism of remdesivir-induced bradycardia and diagnostic and management strategies for these patients. We conclude that further research is necessary to understand better the mechanism of bradycardia in coronavirus disease 2019 patients with or without cardiovascular disorder treated with remdesivir.

Original language	English (US)
Pages (from-to)	317-320
Number of pages	4
Journal	Southern Medical Journal
Volume	116
Issue number	3
DOIs	https://doi.org/10.14423/SMJ.0000000000001519
State	Published - Mar 1 2023

All Science Journal Classification (ASJC) codes

General Medicine

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10.14423/SMJ.0000000000001519

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title = "Remdesivir-Induced Bradycardia",

abstract = "Remdesivir, a viral RNA-dependent RNA polymerase inhibitor, found extensive use in coronavirus disease 2019-infected patients because it curbs the viral load expansion. Among patients hospitalized as a result of lower respiratory tract infection, remdesivir proved to improve recovery time; however, remdesivir also can induce significant cytotoxic effects on cardiac myocytes. In this narrative review, we discuss the pathophysiological mechanism of remdesivir-induced bradycardia and diagnostic and management strategies for these patients. We conclude that further research is necessary to understand better the mechanism of bradycardia in coronavirus disease 2019 patients with or without cardiovascular disorder treated with remdesivir.",

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T1 - Remdesivir-Induced Bradycardia

AU - Kanagala, Sai Gautham

AU - Dholiya, Hardeep

AU - Jhajj, Poonam

AU - Patel, Meet A.

AU - Gupta, Vasu

AU - Gupta, Sachin

AU - Wu, Shiau Ing

AU - Jain, Rohit

PY - 2023/3/1

Y1 - 2023/3/1

N2 - Remdesivir, a viral RNA-dependent RNA polymerase inhibitor, found extensive use in coronavirus disease 2019-infected patients because it curbs the viral load expansion. Among patients hospitalized as a result of lower respiratory tract infection, remdesivir proved to improve recovery time; however, remdesivir also can induce significant cytotoxic effects on cardiac myocytes. In this narrative review, we discuss the pathophysiological mechanism of remdesivir-induced bradycardia and diagnostic and management strategies for these patients. We conclude that further research is necessary to understand better the mechanism of bradycardia in coronavirus disease 2019 patients with or without cardiovascular disorder treated with remdesivir.

AB - Remdesivir, a viral RNA-dependent RNA polymerase inhibitor, found extensive use in coronavirus disease 2019-infected patients because it curbs the viral load expansion. Among patients hospitalized as a result of lower respiratory tract infection, remdesivir proved to improve recovery time; however, remdesivir also can induce significant cytotoxic effects on cardiac myocytes. In this narrative review, we discuss the pathophysiological mechanism of remdesivir-induced bradycardia and diagnostic and management strategies for these patients. We conclude that further research is necessary to understand better the mechanism of bradycardia in coronavirus disease 2019 patients with or without cardiovascular disorder treated with remdesivir.

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Remdesivir-Induced Bradycardia

Abstract

All Science Journal Classification (ASJC) codes

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