Renal iodine¹²³-metaiodobenzylguanidine scintigraphy relates to muscle sympathetic nervous activity in heart failure with reduced ejection fraction

Background: Renal denervation is effective for modulating augmented sympathetic nerve activity (SNA) in heart failure with reduced ejection fraction (HFrEF). We have demonstrated that renal iodine¹²³-metaiodobenzylguanidine (¹²³I-MIBG) scintigraphy is associated with muscle sympathetic nerve activity (MSNA) in patients with hypertension. However, it is unclear whether renal ¹²³I-MIBG scintigraphy is useful for assessment of SNA in HFrEF. Methods: The study population consisted of 24 HFrEF patients and 11 healthy subjects as controls. Patients with HFrEF underwent ¹²³I-MIBG scintigraphy and hemodynamics using a Swan-Ganz catheter (SGC). HFrEF was defined as echocardiography with left ventricular ejection fraction (LVEF) < 50%. MSNA was measured from the peroneal nerve for direct evaluation of SNA. Renal ¹²³I-MIBG scintigraphy was performed simultaneously with cardiac scintigraphy. The early and delayed kidney-to-mediastinum ratio (K/M), early and delayed heart-to-mediastinum ratio (H/M), and washout rate (WR) were calculated. Results: LVEFs were 35% ± 11% in patients with HFrEF and 63% ± 10% in the controls (p < 0.01). The WR of cardiac ¹²³I-MIBG showed no relation to MSNA, but was related to stroke volume (r = 0.45, p < 0.05). In contrast, the WR of renal ¹²³I-MIBG scintigraphy (average of both sides) showed a strong correlation with MSNA (BI, r = 0.70, p < 0.01; BF, r = 0.66, p < 0.01); however, no significant correlations were detected between renal ¹²³I-MIBG scintigraphy and SGC results. Conclusions: The WR of renal ¹²³I-MIBG scintigraphy may reflect MSNA. Further studies are needed to clarify the relationship between renal ¹²³I-MIBG imaging and renal SNA.