Amy C. Arnold, Debra I. Diz

Research output: Chapter in Book/Report/Conference proceedingChapter


The renin-angiotensin system (RAS) is a widely recognized regulator of cardiovascular control, under both physiological and pathophysiological conditions. Pharmacological therapies targeting this hormonal system are used routinely for treatment of hypertension and cardiovascular disease. Accumulating evidence supports involvement of the autonomic nervous system (ANS) in the cardiovascular effects of the RAS, and vice versa, with angiotensin peptides influencing both sympathetic and parasympathetic activity via receptors localized to the brain, spinal cord, ganglia, and vasculature. This chapter highlights clinical and experimental evidence for ANS-RAS interactions integral to normal cardiovascular control and to pathophysiology.

Original languageEnglish (US)
Title of host publicationPrimer on the Autonomic Nervous System, Fourth Edition
Number of pages6
ISBN (Electronic)9780323854924
ISBN (Print)9780323854931
StatePublished - Jan 1 2022

All Science Journal Classification (ASJC) codes

  • General Medicine
  • General Neuroscience

Cite this