Abstract
The renin-angiotensin system (RAS) is a widely recognized regulator of cardiovascular control, under both physiological and pathophysiological conditions. Pharmacological therapies targeting this hormonal system are used routinely for treatment of hypertension and cardiovascular disease. Accumulating evidence supports involvement of the autonomic nervous system (ANS) in the cardiovascular effects of the RAS, and vice versa, with angiotensin peptides influencing both sympathetic and parasympathetic activity via receptors localized to the brain, spinal cord, ganglia, and vasculature. This chapter highlights clinical and experimental evidence for ANS-RAS interactions integral to normal cardiovascular control and to pathophysiology.
Original language | English (US) |
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Title of host publication | Primer on the Autonomic Nervous System, Fourth Edition |
Publisher | Elsevier |
Pages | 113-118 |
Number of pages | 6 |
ISBN (Electronic) | 9780323854924 |
ISBN (Print) | 9780323854931 |
DOIs | |
State | Published - Jan 1 2022 |
All Science Journal Classification (ASJC) codes
- General Medicine
- General Neuroscience