Renohepatic crosstalk: a review of the effects of acute kidney injury on the liver

Anthony Bonavia, Nicholas Stiles

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Several theories regarding acute kidney injury (AKI)-related mortality have been entertained, although mounting evidence supports the paradigm that impaired kidney function directly and adversely affects the function of several remote organs. The kidneys and liver are fundamental to human metabolism and detoxification, and it is therefore hardly surprising that critical illness complicated by hepatorenal dysfunction portends a poor prognosis. Several diseases can simultaneously impact the proper functioning of the liver and kidneys, although this review will address the impact of AKI on liver function. While evidence for this relationship in humans remains sparse, we present supportive studies and then discuss the most likely mechanisms by which AKI can cause liver dysfunction. These include ‘traditional’ complications of AKI (uremia, volume overload and acute metabolic acidosis, among others) as well as systemic inflammation, hepatic leukocyte infiltration, cytokine-mediated liver injury and hepatic oxidative stress. We conclude by addressing the therapeutic implications of these findings to clinical medicine.

Original languageEnglish (US)
Pages (from-to)1218-1228
Number of pages11
JournalNephrology Dialysis Transplantation
Issue number7
StatePublished - Jul 1 2022

All Science Journal Classification (ASJC) codes

  • Nephrology
  • Transplantation


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