Repair Mechanisms and Initiation in Carcinogenesis

Abbey M. Rebok; Thomas E. Spratt

doi:10.1016/B978-0-323-95488-4.00089-9

Repair Mechanisms and Initiation in Carcinogenesis

Abbey M. Rebok
, Thomas E. Spratt

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Cancer is a worldwide health problem in that one out of five people will develop cancer and one in six of all deaths will be caused by cancer. Cancer is the result of a multi-step process that begins with DNA damage caused by endogenous and exogenous sources. Eukaryotic cells have evolved DNA damage response mechanisms that respond to the damage. These mechanisms include damage identification, cell cycle checkpoints, DNA repair and DNA tolerance pathways. If these pathways do not operate accurately then mutations occur that can initiate carcinogenesis.

Original language	English (US)
Title of host publication	Comprehensive Toxicology
Publisher	Elsevier
Pages	Vol13:45-Vol15:81
ISBN (Electronic)	9780323954884
ISBN (Print)	9780323954891
DOIs	https://doi.org/10.1016/B978-0-323-95488-4.00089-9
State	Published - Jan 1 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

General Medicine

Access to Document

10.1016/B978-0-323-95488-4.00089-9

Cite this

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AB - Cancer is a worldwide health problem in that one out of five people will develop cancer and one in six of all deaths will be caused by cancer. Cancer is the result of a multi-step process that begins with DNA damage caused by endogenous and exogenous sources. Eukaryotic cells have evolved DNA damage response mechanisms that respond to the damage. These mechanisms include damage identification, cell cycle checkpoints, DNA repair and DNA tolerance pathways. If these pathways do not operate accurately then mutations occur that can initiate carcinogenesis.

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ER -

Repair Mechanisms and Initiation in Carcinogenesis

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

Access to Document

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