TY - JOUR
T1 - Research priorities for therapeutic plasma exchange in critically ill patients
AU - for the Nine-I investigators
AU - David, Sascha
AU - Russell, Lene
AU - Castro, Pedro
AU - van de Louw, Andry
AU - Zafrani, Lara
AU - Pirani, Tasneem
AU - Nielsen, Nathan D.
AU - Mariotte, Eric
AU - Ferreyro, Bruno L.
AU - Kielstein, Jan T.
AU - Montini, Luca
AU - Brignier, Anne C.
AU - Kochanek, Matthias
AU - Cid, Joan
AU - Robba, Chiara
AU - Martin-Loeches, Ignacio
AU - Ostermann, Marlies
AU - Juffermans, Nicole P.
N1 - Publisher Copyright:
© 2023, The Author(s).
PY - 2023/12
Y1 - 2023/12
N2 - Therapeutic plasma exchange (TPE) is a therapeutic intervention that separates plasma from blood cells to remove pathological factors or to replenish deficient factors. The use of TPE is increasing over the last decades. However, despite a good theoretical rationale and biological plausibility for TPE as a therapy for numerous diseases or syndromes associated with critical illness, TPE in the intensive care unit (ICU) setting has not been studied extensively. A group of eighteen experts around the globe from different clinical backgrounds used a modified Delphi method to phrase key research questions related to “TPE in the critically ill patient”. These questions focused on: (1) the pathophysiological role of the removal and replacement process, (2) optimal timing of treatment, (3) dosing and treatment regimes, (4) risk–benefit assumptions and (5) novel indications in need of exploration. For all five topics, the current understanding as well as gaps in knowledge and future directions were assessed. The content should stimulate future research in the field and novel clinical applications.
AB - Therapeutic plasma exchange (TPE) is a therapeutic intervention that separates plasma from blood cells to remove pathological factors or to replenish deficient factors. The use of TPE is increasing over the last decades. However, despite a good theoretical rationale and biological plausibility for TPE as a therapy for numerous diseases or syndromes associated with critical illness, TPE in the intensive care unit (ICU) setting has not been studied extensively. A group of eighteen experts around the globe from different clinical backgrounds used a modified Delphi method to phrase key research questions related to “TPE in the critically ill patient”. These questions focused on: (1) the pathophysiological role of the removal and replacement process, (2) optimal timing of treatment, (3) dosing and treatment regimes, (4) risk–benefit assumptions and (5) novel indications in need of exploration. For all five topics, the current understanding as well as gaps in knowledge and future directions were assessed. The content should stimulate future research in the field and novel clinical applications.
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U2 - 10.1186/s40635-023-00510-w
DO - 10.1186/s40635-023-00510-w
M3 - Review article
C2 - 37150798
AN - SCOPUS:85158937880
SN - 2197-425X
VL - 11
JO - Intensive Care Medicine Experimental
JF - Intensive Care Medicine Experimental
IS - 1
M1 - 26
ER -