Resistance to quorum-quenching compounds

Rodolfo García-Contreras, Toshinari Maeda, Thomas K. Wood

Research output: Contribution to journalReview articlepeer-review

85 Scopus citations


Bacteria have the remarkable ability to communicate as a group in what has become known as quorum sensing (QS), and this trait has been associated with important bacterial phenotypes, such as virulence and biofilm formation. Bacteria also have an incredible ability to evolve resistance to all known antimicrobials. Hence, although inhibition of QS has been hailed as a means to reduce virulence in a manner that is impervious to bacterial resistance mechanisms, this approach is unlikely to be a panacea. Here we review the evidence that bacteria can evolve resistance to quorum-quenching compounds.

Original languageEnglish (US)
Pages (from-to)6840-6846
Number of pages7
JournalApplied and environmental microbiology
Issue number22
StatePublished - Nov 2013

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology
  • Ecology


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