Response of mature mice to challenge with neuroblastoma after inoculation with neuroblastoma cells as neonates

Cara Lynne Schengrund; Mary Ann Repman; Beth A. Sheffler

doi:10.1016/0304-3835(82)90037-4

Response of mature mice to challenge with neuroblastoma after inoculation with neuroblastoma cells as neonates

Cara Lynne Schengrund, Mary Ann Repman, Beth A. Sheffler

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Injection (s.c.) of 2 × 10⁵ S20Y neuroblastoma cells into adult A J strain mice regularly produced a higher incidence of progressive, lethal tumor growth. In contrast, successful tumor growth was significantly less frequent (P<0.001) when the same number of tumor cells were injected into neonatal A J mice. A significant number (P<0.001) of matured mice that had rejected the initial S20Y cell inoculum as neonates were able to reject 2 subsequent challenges with S20Y cells.

Original language	English (US)
Pages (from-to)	229-235
Number of pages	7
Journal	Cancer Letters
Volume	17
Issue number	2
DOIs	https://doi.org/10.1016/0304-3835(82)90037-4
State	Published - 1982

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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10.1016/0304-3835(82)90037-4

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title = "Response of mature mice to challenge with neuroblastoma after inoculation with neuroblastoma cells as neonates",

abstract = "Injection (s.c.) of 2 × 105 S20Y neuroblastoma cells into adult A J strain mice regularly produced a higher incidence of progressive, lethal tumor growth. In contrast, successful tumor growth was significantly less frequent (P<0.001) when the same number of tumor cells were injected into neonatal A J mice. A significant number (P<0.001) of matured mice that had rejected the initial S20Y cell inoculum as neonates were able to reject 2 subsequent challenges with S20Y cells.",

author = "Schengrund, {Cara Lynne} and Repman, {Mary Ann} and Sheffler, {Beth A.}",

note = "Funding Information: We thank Dr. G. Barlett for helpful discussions. Supported by grants CA14319 and CA18450 awarded by the National Cancer Institute.",

year = "1982",

doi = "10.1016/0304-3835(82)90037-4",

language = "English (US)",

volume = "17",

pages = "229--235",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

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TY - JOUR

T1 - Response of mature mice to challenge with neuroblastoma after inoculation with neuroblastoma cells as neonates

AU - Schengrund, Cara Lynne

AU - Repman, Mary Ann

AU - Sheffler, Beth A.

N1 - Funding Information: We thank Dr. G. Barlett for helpful discussions. Supported by grants CA14319 and CA18450 awarded by the National Cancer Institute.

PY - 1982

Y1 - 1982

N2 - Injection (s.c.) of 2 × 105 S20Y neuroblastoma cells into adult A J strain mice regularly produced a higher incidence of progressive, lethal tumor growth. In contrast, successful tumor growth was significantly less frequent (P<0.001) when the same number of tumor cells were injected into neonatal A J mice. A significant number (P<0.001) of matured mice that had rejected the initial S20Y cell inoculum as neonates were able to reject 2 subsequent challenges with S20Y cells.

AB - Injection (s.c.) of 2 × 105 S20Y neuroblastoma cells into adult A J strain mice regularly produced a higher incidence of progressive, lethal tumor growth. In contrast, successful tumor growth was significantly less frequent (P<0.001) when the same number of tumor cells were injected into neonatal A J mice. A significant number (P<0.001) of matured mice that had rejected the initial S20Y cell inoculum as neonates were able to reject 2 subsequent challenges with S20Y cells.

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SN - 0304-3835

VL - 17

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JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Response of mature mice to challenge with neuroblastoma after inoculation with neuroblastoma cells as neonates

Abstract

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