Response of mature mice to challenge with neuroblastoma after inoculation with neuroblastoma cells as neonates

Cara Lynne Schengrund; Mary Ann Repman; Beth A. Sheffler

doi:10.1016/0304-3835(82)90037-4

Response of mature mice to challenge with neuroblastoma after inoculation with neuroblastoma cells as neonates

Cara Lynne Schengrund
, Mary Ann Repman
, Beth A. Sheffler

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Injection (s.c.) of 2 × 10⁵ S20Y neuroblastoma cells into adult A J strain mice regularly produced a higher incidence of progressive, lethal tumor growth. In contrast, successful tumor growth was significantly less frequent (P<0.001) when the same number of tumor cells were injected into neonatal A J mice. A significant number (P<0.001) of matured mice that had rejected the initial S20Y cell inoculum as neonates were able to reject 2 subsequent challenges with S20Y cells.

Original language	English (US)
Pages (from-to)	229-235
Number of pages	7
Journal	Cancer Letters
Volume	17
Issue number	2
DOIs	https://doi.org/10.1016/0304-3835(82)90037-4
State	Published - 1982

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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10.1016/0304-3835(82)90037-4

Cite this

@article{6dfb1ba26e4548528b9300c51cdbf3a7,

title = "Response of mature mice to challenge with neuroblastoma after inoculation with neuroblastoma cells as neonates",

abstract = "Injection (s.c.) of 2 × 105 S20Y neuroblastoma cells into adult A J strain mice regularly produced a higher incidence of progressive, lethal tumor growth. In contrast, successful tumor growth was significantly less frequent (P<0.001) when the same number of tumor cells were injected into neonatal A J mice. A significant number (P<0.001) of matured mice that had rejected the initial S20Y cell inoculum as neonates were able to reject 2 subsequent challenges with S20Y cells.",

author = "Schengrund, \{Cara Lynne\} and Repman, \{Mary Ann\} and Sheffler, \{Beth A.\}",

note = "Funding Information: We thank Dr. G. Barlett for helpful discussions. Supported by grants CA14319 and CA18450 awarded by the National Cancer Institute.",

year = "1982",

doi = "10.1016/0304-3835(82)90037-4",

language = "English (US)",

volume = "17",

pages = "229--235",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - Response of mature mice to challenge with neuroblastoma after inoculation with neuroblastoma cells as neonates

AU - Schengrund, Cara Lynne

AU - Repman, Mary Ann

AU - Sheffler, Beth A.

N1 - Funding Information: We thank Dr. G. Barlett for helpful discussions. Supported by grants CA14319 and CA18450 awarded by the National Cancer Institute.

PY - 1982

Y1 - 1982

N2 - Injection (s.c.) of 2 × 105 S20Y neuroblastoma cells into adult A J strain mice regularly produced a higher incidence of progressive, lethal tumor growth. In contrast, successful tumor growth was significantly less frequent (P<0.001) when the same number of tumor cells were injected into neonatal A J mice. A significant number (P<0.001) of matured mice that had rejected the initial S20Y cell inoculum as neonates were able to reject 2 subsequent challenges with S20Y cells.

AB - Injection (s.c.) of 2 × 105 S20Y neuroblastoma cells into adult A J strain mice regularly produced a higher incidence of progressive, lethal tumor growth. In contrast, successful tumor growth was significantly less frequent (P<0.001) when the same number of tumor cells were injected into neonatal A J mice. A significant number (P<0.001) of matured mice that had rejected the initial S20Y cell inoculum as neonates were able to reject 2 subsequent challenges with S20Y cells.

UR - https://www.scopus.com/pages/publications/0020366539

UR - https://www.scopus.com/pages/publications/0020366539#tab=citedBy

U2 - 10.1016/0304-3835(82)90037-4

DO - 10.1016/0304-3835(82)90037-4

M3 - Article

C2 - 7165874

AN - SCOPUS:0020366539

SN - 0304-3835

VL - 17

SP - 229

EP - 235

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Response of mature mice to challenge with neuroblastoma after inoculation with neuroblastoma cells as neonates

Abstract

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