TY - JOUR
T1 - Responses of sympathetic outflow to skin during caloric stimulation in humans
AU - Cui, Jian
AU - Iwase, Satoshi
AU - Mano, Tadaaki
AU - Kitazawa, Hiroki
PY - 1999/3
Y1 - 1999/3
N2 - We previously showed that caloric vestibular stimulation elicits increases in sympathetic outflow to muscle (MSNA) in humans. The present study was conducted to determine the effect of this stimulation on sympathetic outflow to skin (SSNA). The SSNA in the tibial and peroneal nerves and nystagmus was recorded in nine subjects when the external meatus was irrigated with 50 ml of cold (10°C) or warm (44°C) water. During nystagmus, the SSNA in tibial and peroneal nerves decreased to 50 ± 4% (with baseline value set as 100%) and 61 ± 4%, respectively. The degree of SSNA suppression in both nerves was proportional to the maximum slow-phase velocity of nystagmus. After nystagmus, the SSNA increased to 166 ± 7 and 168 ± 6%, respectively, and the degree of motion sickness symptoms was correlated with this SSNA increase. These results suggest that the SSNA response differs from the MSNA response during caloric vestibular stimulation and that the SSNA response elicited in the initial period of caloric vestibular stimulation is different from that observed during the period of motion sickness symptoms.
AB - We previously showed that caloric vestibular stimulation elicits increases in sympathetic outflow to muscle (MSNA) in humans. The present study was conducted to determine the effect of this stimulation on sympathetic outflow to skin (SSNA). The SSNA in the tibial and peroneal nerves and nystagmus was recorded in nine subjects when the external meatus was irrigated with 50 ml of cold (10°C) or warm (44°C) water. During nystagmus, the SSNA in tibial and peroneal nerves decreased to 50 ± 4% (with baseline value set as 100%) and 61 ± 4%, respectively. The degree of SSNA suppression in both nerves was proportional to the maximum slow-phase velocity of nystagmus. After nystagmus, the SSNA increased to 166 ± 7 and 168 ± 6%, respectively, and the degree of motion sickness symptoms was correlated with this SSNA increase. These results suggest that the SSNA response differs from the MSNA response during caloric vestibular stimulation and that the SSNA response elicited in the initial period of caloric vestibular stimulation is different from that observed during the period of motion sickness symptoms.
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U2 - 10.1152/ajpregu.1999.276.3.r738
DO - 10.1152/ajpregu.1999.276.3.r738
M3 - Article
C2 - 10070134
AN - SCOPUS:0032953982
SN - 0363-6119
VL - 276
SP - R738-R744
JO - American Journal of Physiology - Regulatory Integrative and Comparative Physiology
JF - American Journal of Physiology - Regulatory Integrative and Comparative Physiology
IS - 3 45-3
ER -