Rethinking vector immunology: The role of environmental temperature in shaping resistance

Courtney C. Murdock; Krijn P. Paaijmans; Diana Cox-Foster; Andrew F. Read; Matthew B. Thomas

doi:10.1038/nrmicro2900

Rethinking vector immunology: The role of environmental temperature in shaping resistance

Courtney C. Murdock
, Krijn P. Paaijmans
, Diana Cox-Foster
, Andrew F. Read
, Matthew B. Thomas

Research output: Contribution to journal › Review article › peer-review

123 Scopus citations

Abstract

Recent ecological research has revealed that environmental factors can strongly affect insect immunity and influence the outcome of host-parasite interactions. To date, however, most studies examining immune function in mosquitoes have ignored environmental variability. We argue that one such environmental variable, temperature, influences both vector immunity and the parasite itself. As temperatures in the field can vary greatly from the ambient temperature in the laboratory, it will be essential to take temperature into account when studying vector immunology.

Original language	English (US)
Pages (from-to)	869-876
Number of pages	8
Journal	Nature Reviews Microbiology
Volume	10
Issue number	12
DOIs	https://doi.org/10.1038/nrmicro2900
State	Published - Dec 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Microbiology
General Immunology and Microbiology
Infectious Diseases

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10.1038/nrmicro2900

Cite this

@article{cf0f91a14f22471a8626903a724f13fd,

title = "Rethinking vector immunology: The role of environmental temperature in shaping resistance",

abstract = "Recent ecological research has revealed that environmental factors can strongly affect insect immunity and influence the outcome of host-parasite interactions. To date, however, most studies examining immune function in mosquitoes have ignored environmental variability. We argue that one such environmental variable, temperature, influences both vector immunity and the parasite itself. As temperatures in the field can vary greatly from the ambient temperature in the laboratory, it will be essential to take temperature into account when studying vector immunology.",

author = "Murdock, \{Courtney C.\} and Paaijmans, \{Krijn P.\} and Diana Cox-Foster and Read, \{Andrew F.\} and Thomas, \{Matthew B.\}",

note = "Funding Information: The authors thank members of the Thomas, Read and Julian F. Hillyer laboratory groups for discussion, and D. Kroczynski and J. Teeple for insectary support. The content of this article is solely the responsibility of the authors and does not necessarily represent the official views of the US National Institute of General Medical Sciences, the US National Institute of Allergy and Infectious Diseases or the US National Institutes of Health (NIH). Work in the authors{\textquoteright} laboratories is funded, in part, by a grant from the US Pennsylvania Department of Health using Tobacco Settlement Funds. The Pennsylvania Department of Health specifically disclaims responsibility for any analyses, interpretations or conclusions. Work in the authors{\textquoteright} laboratories was also funded by the following: the US National Science Foundation (NSF)–NIH Ecology of Infectious Diseases programme (grant EF-0914384) and the NIH R21 programme (grant AI096036-01).",

year = "2012",

month = dec,

doi = "10.1038/nrmicro2900",

language = "English (US)",

volume = "10",

pages = "869--876",

journal = "Nature Reviews Microbiology",

issn = "1740-1526",

publisher = "Nature Research",

number = "12",

}

TY - JOUR

T1 - Rethinking vector immunology

T2 - The role of environmental temperature in shaping resistance

AU - Murdock, Courtney C.

AU - Paaijmans, Krijn P.

AU - Cox-Foster, Diana

AU - Read, Andrew F.

AU - Thomas, Matthew B.

N1 - Funding Information: The authors thank members of the Thomas, Read and Julian F. Hillyer laboratory groups for discussion, and D. Kroczynski and J. Teeple for insectary support. The content of this article is solely the responsibility of the authors and does not necessarily represent the official views of the US National Institute of General Medical Sciences, the US National Institute of Allergy and Infectious Diseases or the US National Institutes of Health (NIH). Work in the authors’ laboratories is funded, in part, by a grant from the US Pennsylvania Department of Health using Tobacco Settlement Funds. The Pennsylvania Department of Health specifically disclaims responsibility for any analyses, interpretations or conclusions. Work in the authors’ laboratories was also funded by the following: the US National Science Foundation (NSF)–NIH Ecology of Infectious Diseases programme (grant EF-0914384) and the NIH R21 programme (grant AI096036-01).

PY - 2012/12

Y1 - 2012/12

N2 - Recent ecological research has revealed that environmental factors can strongly affect insect immunity and influence the outcome of host-parasite interactions. To date, however, most studies examining immune function in mosquitoes have ignored environmental variability. We argue that one such environmental variable, temperature, influences both vector immunity and the parasite itself. As temperatures in the field can vary greatly from the ambient temperature in the laboratory, it will be essential to take temperature into account when studying vector immunology.

AB - Recent ecological research has revealed that environmental factors can strongly affect insect immunity and influence the outcome of host-parasite interactions. To date, however, most studies examining immune function in mosquitoes have ignored environmental variability. We argue that one such environmental variable, temperature, influences both vector immunity and the parasite itself. As temperatures in the field can vary greatly from the ambient temperature in the laboratory, it will be essential to take temperature into account when studying vector immunology.

UR - https://www.scopus.com/pages/publications/84869235043

UR - https://www.scopus.com/pages/publications/84869235043#tab=citedBy

U2 - 10.1038/nrmicro2900

DO - 10.1038/nrmicro2900

M3 - Review article

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AN - SCOPUS:84869235043

SN - 1740-1526

VL - 10

SP - 869

EP - 876

JO - Nature Reviews Microbiology

JF - Nature Reviews Microbiology

IS - 12

ER -

Rethinking vector immunology: The role of environmental temperature in shaping resistance

Abstract

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