TY - JOUR
T1 - Retinal ganglion cells in diabetes
AU - Kern, Timothy S.
AU - Barber, Alistair J.
PY - 2008
Y1 - 2008
N2 - Diabetic retinopathy has long been recognized as a vascular disease that develops in most patients, and it was believed that the visual dysfunction that develops in some diabetics was due to the vascular lesions used to characterize the disease. It is becoming increasingly clear that neuronal cells of the retina also are affected by diabetes, resulting in dysfunction and even degeneration of some neuronal cells. Retinal ganglion cells (RGCs) are the best studied of the retinal neurons with respect to the effect of diabetes. Although investigations are providing new information about RGCs in diabetes, including therapies to inhibit the neurodegeneration, critical information about the function, anatomy and response properties of these cells is yet needed to understand the relationship between RGC changes and visual dysfunction in diabetes.
AB - Diabetic retinopathy has long been recognized as a vascular disease that develops in most patients, and it was believed that the visual dysfunction that develops in some diabetics was due to the vascular lesions used to characterize the disease. It is becoming increasingly clear that neuronal cells of the retina also are affected by diabetes, resulting in dysfunction and even degeneration of some neuronal cells. Retinal ganglion cells (RGCs) are the best studied of the retinal neurons with respect to the effect of diabetes. Although investigations are providing new information about RGCs in diabetes, including therapies to inhibit the neurodegeneration, critical information about the function, anatomy and response properties of these cells is yet needed to understand the relationship between RGC changes and visual dysfunction in diabetes.
UR - http://www.scopus.com/inward/record.url?scp=51849157860&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=51849157860&partnerID=8YFLogxK
U2 - 10.1113/jphysiol.2008.156695
DO - 10.1113/jphysiol.2008.156695
M3 - Article
C2 - 18565995
AN - SCOPUS:51849157860
SN - 0022-3751
VL - 586
SP - 4401
EP - 4408
JO - Journal of Physiology
JF - Journal of Physiology
IS - 18
ER -