Retinoic acid induces transforming growth factor-beta 2 in cultured keratinocytes and mouse epidermis.

A. B. Glick; K. C. Flanders; D. Danielpour; S. H. Yuspa; M. B. Sporn

doi:10.1091/mbc.1.1.87

Retinoic acid induces transforming growth factor-beta 2 in cultured keratinocytes and mouse epidermis.

A. B. Glick, K. C. Flanders, D. Danielpour, S. H. Yuspa, M. B. Sporn

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Abstract

We have studied the functional interaction between retinoic acid and transforming growth factor-beta (TGF-beta), using the mouse epidermis as a model system. Treatment with retinoic acid increases expression of TGF-beta 2 in cultured keratinocytes in vitro, as well as in the epidermis in vivo. This TGF-beta 2 is secreted in a biologically active form that can bind to surface receptors, in contrast to most other conditions in which TGF-beta is secreted in a latent form. Specific antibodies to TGF-beta 2 partially reverse the ability of retinoic acid to inhibit DNA synthesis in cultured keratinocytes. The regulation of TGF-beta 2 expression by retinoic acid may have important physiological and pharmacological roles in the maintenance of epidermal homeostasis.

Original language	English (US)
Pages (from-to)	87-97
Number of pages	11
Journal	Cell regulation
Volume	1
Issue number	1
DOIs	https://doi.org/10.1091/mbc.1.1.87
State	Published - Nov 1989

All Science Journal Classification (ASJC) codes

General Medicine

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abstract = "We have studied the functional interaction between retinoic acid and transforming growth factor-beta (TGF-beta), using the mouse epidermis as a model system. Treatment with retinoic acid increases expression of TGF-beta 2 in cultured keratinocytes in vitro, as well as in the epidermis in vivo. This TGF-beta 2 is secreted in a biologically active form that can bind to surface receptors, in contrast to most other conditions in which TGF-beta is secreted in a latent form. Specific antibodies to TGF-beta 2 partially reverse the ability of retinoic acid to inhibit DNA synthesis in cultured keratinocytes. The regulation of TGF-beta 2 expression by retinoic acid may have important physiological and pharmacological roles in the maintenance of epidermal homeostasis.",

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AU - Sporn, M. B.

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AB - We have studied the functional interaction between retinoic acid and transforming growth factor-beta (TGF-beta), using the mouse epidermis as a model system. Treatment with retinoic acid increases expression of TGF-beta 2 in cultured keratinocytes in vitro, as well as in the epidermis in vivo. This TGF-beta 2 is secreted in a biologically active form that can bind to surface receptors, in contrast to most other conditions in which TGF-beta is secreted in a latent form. Specific antibodies to TGF-beta 2 partially reverse the ability of retinoic acid to inhibit DNA synthesis in cultured keratinocytes. The regulation of TGF-beta 2 expression by retinoic acid may have important physiological and pharmacological roles in the maintenance of epidermal homeostasis.

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Retinoic acid induces transforming growth factor-beta 2 in cultured keratinocytes and mouse epidermis.

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