Retraction Note: BICC1 drives pancreatic cancer progression by inducing VEGF-independent angiogenesis(Signal Transduction and Targeted Therapy, 10.1038/s41392-023-01478-5)

Chongbiao Huang; Hui Li; Yang Xu; Chao Xu; Huizhi Sun; Zengxun Li; Yi Ge; Hongwei Wang; Tiansuo Zhao; Song Gao; Xiuchao Wang; Shengyu Yang; Peiqing Sun; Zhe Liu; Jing Liu; Antao Chang; Jihui Hao

doi:10.1038/s41392-025-02561-9

Retraction Note: BICC1 drives pancreatic cancer progression by inducing VEGF-independent angiogenesis(Signal Transduction and Targeted Therapy, 10.1038/s41392-023-01478-5)

Chongbiao Huang
, Hui Li
, Yang Xu
, Chao Xu
, Huizhi Sun
, Zengxun Li
, Yi Ge
, Hongwei Wang
, Tiansuo Zhao
, Song Gao
, Xiuchao Wang
, Shengyu Yang
, Peiqing Sun
, Zhe Liu
, Jing Liu
, Antao Chang
, Jihui Hao

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Retraction to: Signal Transduction and Targeted Therapyhttps://doi.org/10.1038/s41392-023-01478-5, published online 14 July 2023 The Editors have retracted this article. After publication, a number of image integrity concerns were raised. Specifically: Two panels in figure 4F appear to overlap representing BICC1, BICC1+LCN2ab, and BICC1, BICC1+CXCL1ab, which was subsequently corrected. Figure S10b BxPC-3 BICC1 SN+VEGFAab appears to overlap with figure S10c KPC BICC1 SN. Figure S10b AsPC-1 BICC1 SN+VEGFAab appears to overlap with figure S11b BICC1 SN LCN2ab -, BxPC-3. Figure S10b AsPC-1 BICC1 SN appears to overlap with figure S11b BICC1 SN LCN2ab -, AsPC-1. Figure S11c vector SN CXCL1ab - BxPC-3 appears to overlap with Figure S11d CFPAC-1 rhLCN2 30 min CXCL1ab -. Figure S4e furthest left mouse image for Pan02 shBICC1 appears to overlap with figure S12b furthest left mouse image for KPC vector. Two panels in figure 4F appear to overlap representing BICC1, BICC1+LCN2ab, and BICC1, BICC1+CXCL1ab, which was subsequently corrected. Figure S10b BxPC-3 BICC1 SN+VEGFAab appears to overlap with figure S10c KPC BICC1 SN. Figure S10b AsPC-1 BICC1 SN+VEGFAab appears to overlap with figure S11b BICC1 SN LCN2ab -, BxPC-3. Figure S10b AsPC-1 BICC1 SN appears to overlap with figure S11b BICC1 SN LCN2ab -, AsPC-1. Figure S11c vector SN CXCL1ab - BxPC-3 appears to overlap with Figure S11d CFPAC-1 rhLCN2 30 min CXCL1ab -. Figure S4e furthest left mouse image for Pan02 shBICC1 appears to overlap with figure S12b furthest left mouse image for KPC vector. The Editors have lost confidence in the data and conclusions of this article. Author Shengyu Yang agrees with this retraction. All other authors did not respond to correspondence from the publisher regarding this retraction.

Original language	English (US)
Article number	4
Journal	Signal Transduction and Targeted Therapy
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41392-025-02561-9
State	Published - Dec 2026

All Science Journal Classification (ASJC) codes

Genetics
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41392-025-02561-9

Cite this

Huang, C., Li, H., Xu, Y., Xu, C., Sun, H., Li, Z., Ge, Y., Wang, H., Zhao, T., Gao, S., Wang, X., Yang, S., Sun, P., Liu, Z., Liu, J., Chang, A., & Hao, J. (2026). Retraction Note: BICC1 drives pancreatic cancer progression by inducing VEGF-independent angiogenesis(Signal Transduction and Targeted Therapy, 10.1038/s41392-023-01478-5). Signal Transduction and Targeted Therapy, 11(1), Article 4. https://doi.org/10.1038/s41392-025-02561-9

@article{feee078729474b429c818fe5800985eb,

title = "Retraction Note: BICC1 drives pancreatic cancer progression by inducing VEGF-independent angiogenesis(Signal Transduction and Targeted Therapy, 10.1038/s41392-023-01478-5)",

abstract = "Retraction to: Signal Transduction and Targeted Therapyhttps://doi.org/10.1038/s41392-023-01478-5, published online 14 July 2023 The Editors have retracted this article. After publication, a number of image integrity concerns were raised. Specifically: Two panels in figure 4F appear to overlap representing BICC1, BICC1+LCN2ab, and BICC1, BICC1+CXCL1ab, which was subsequently corrected. Figure S10b BxPC-3 BICC1 SN+VEGFAab appears to overlap with figure S10c KPC BICC1 SN. Figure S10b AsPC-1 BICC1 SN+VEGFAab appears to overlap with figure S11b BICC1 SN LCN2ab -, BxPC-3. Figure S10b AsPC-1 BICC1 SN appears to overlap with figure S11b BICC1 SN LCN2ab -, AsPC-1. Figure S11c vector SN CXCL1ab - BxPC-3 appears to overlap with Figure S11d CFPAC-1 rhLCN2 30 min CXCL1ab -. Figure S4e furthest left mouse image for Pan02 shBICC1 appears to overlap with figure S12b furthest left mouse image for KPC vector. Two panels in figure 4F appear to overlap representing BICC1, BICC1+LCN2ab, and BICC1, BICC1+CXCL1ab, which was subsequently corrected. Figure S10b BxPC-3 BICC1 SN+VEGFAab appears to overlap with figure S10c KPC BICC1 SN. Figure S10b AsPC-1 BICC1 SN+VEGFAab appears to overlap with figure S11b BICC1 SN LCN2ab -, BxPC-3. Figure S10b AsPC-1 BICC1 SN appears to overlap with figure S11b BICC1 SN LCN2ab -, AsPC-1. Figure S11c vector SN CXCL1ab - BxPC-3 appears to overlap with Figure S11d CFPAC-1 rhLCN2 30 min CXCL1ab -. Figure S4e furthest left mouse image for Pan02 shBICC1 appears to overlap with figure S12b furthest left mouse image for KPC vector. The Editors have lost confidence in the data and conclusions of this article. Author Shengyu Yang agrees with this retraction. All other authors did not respond to correspondence from the publisher regarding this retraction.",

author = "Chongbiao Huang and Hui Li and Yang Xu and Chao Xu and Huizhi Sun and Zengxun Li and Yi Ge and Hongwei Wang and Tiansuo Zhao and Song Gao and Xiuchao Wang and Shengyu Yang and Peiqing Sun and Zhe Liu and Jing Liu and Antao Chang and Jihui Hao",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2025.",

year = "2026",

month = dec,

doi = "10.1038/s41392-025-02561-9",

language = "English (US)",

volume = "11",

journal = "Signal Transduction and Targeted Therapy",

issn = "2095-9907",

publisher = "Springer Nature",

number = "1",

}

Huang, C, Li, H, Xu, Y, Xu, C, Sun, H, Li, Z, Ge, Y, Wang, H, Zhao, T, Gao, S, Wang, X, Yang, S, Sun, P, Liu, Z, Liu, J, Chang, A & Hao, J 2026, 'Retraction Note: BICC1 drives pancreatic cancer progression by inducing VEGF-independent angiogenesis(Signal Transduction and Targeted Therapy, 10.1038/s41392-023-01478-5)', Signal Transduction and Targeted Therapy, vol. 11, no. 1, 4. https://doi.org/10.1038/s41392-025-02561-9

TY - JOUR

T1 - Retraction Note

T2 - BICC1 drives pancreatic cancer progression by inducing VEGF-independent angiogenesis(Signal Transduction and Targeted Therapy, 10.1038/s41392-023-01478-5)

AU - Huang, Chongbiao

AU - Li, Hui

AU - Xu, Yang

AU - Xu, Chao

AU - Sun, Huizhi

AU - Li, Zengxun

AU - Ge, Yi

AU - Wang, Hongwei

AU - Zhao, Tiansuo

AU - Gao, Song

AU - Wang, Xiuchao

AU - Yang, Shengyu

AU - Sun, Peiqing

AU - Liu, Zhe

AU - Liu, Jing

AU - Chang, Antao

AU - Hao, Jihui

PY - 2026/12

Y1 - 2026/12

N2 - Retraction to: Signal Transduction and Targeted Therapyhttps://doi.org/10.1038/s41392-023-01478-5, published online 14 July 2023 The Editors have retracted this article. After publication, a number of image integrity concerns were raised. Specifically: Two panels in figure 4F appear to overlap representing BICC1, BICC1+LCN2ab, and BICC1, BICC1+CXCL1ab, which was subsequently corrected. Figure S10b BxPC-3 BICC1 SN+VEGFAab appears to overlap with figure S10c KPC BICC1 SN. Figure S10b AsPC-1 BICC1 SN+VEGFAab appears to overlap with figure S11b BICC1 SN LCN2ab -, BxPC-3. Figure S10b AsPC-1 BICC1 SN appears to overlap with figure S11b BICC1 SN LCN2ab -, AsPC-1. Figure S11c vector SN CXCL1ab - BxPC-3 appears to overlap with Figure S11d CFPAC-1 rhLCN2 30 min CXCL1ab -. Figure S4e furthest left mouse image for Pan02 shBICC1 appears to overlap with figure S12b furthest left mouse image for KPC vector. Two panels in figure 4F appear to overlap representing BICC1, BICC1+LCN2ab, and BICC1, BICC1+CXCL1ab, which was subsequently corrected. Figure S10b BxPC-3 BICC1 SN+VEGFAab appears to overlap with figure S10c KPC BICC1 SN. Figure S10b AsPC-1 BICC1 SN+VEGFAab appears to overlap with figure S11b BICC1 SN LCN2ab -, BxPC-3. Figure S10b AsPC-1 BICC1 SN appears to overlap with figure S11b BICC1 SN LCN2ab -, AsPC-1. Figure S11c vector SN CXCL1ab - BxPC-3 appears to overlap with Figure S11d CFPAC-1 rhLCN2 30 min CXCL1ab -. Figure S4e furthest left mouse image for Pan02 shBICC1 appears to overlap with figure S12b furthest left mouse image for KPC vector. The Editors have lost confidence in the data and conclusions of this article. Author Shengyu Yang agrees with this retraction. All other authors did not respond to correspondence from the publisher regarding this retraction.

AB - Retraction to: Signal Transduction and Targeted Therapyhttps://doi.org/10.1038/s41392-023-01478-5, published online 14 July 2023 The Editors have retracted this article. After publication, a number of image integrity concerns were raised. Specifically: Two panels in figure 4F appear to overlap representing BICC1, BICC1+LCN2ab, and BICC1, BICC1+CXCL1ab, which was subsequently corrected. Figure S10b BxPC-3 BICC1 SN+VEGFAab appears to overlap with figure S10c KPC BICC1 SN. Figure S10b AsPC-1 BICC1 SN+VEGFAab appears to overlap with figure S11b BICC1 SN LCN2ab -, BxPC-3. Figure S10b AsPC-1 BICC1 SN appears to overlap with figure S11b BICC1 SN LCN2ab -, AsPC-1. Figure S11c vector SN CXCL1ab - BxPC-3 appears to overlap with Figure S11d CFPAC-1 rhLCN2 30 min CXCL1ab -. Figure S4e furthest left mouse image for Pan02 shBICC1 appears to overlap with figure S12b furthest left mouse image for KPC vector. Two panels in figure 4F appear to overlap representing BICC1, BICC1+LCN2ab, and BICC1, BICC1+CXCL1ab, which was subsequently corrected. Figure S10b BxPC-3 BICC1 SN+VEGFAab appears to overlap with figure S10c KPC BICC1 SN. Figure S10b AsPC-1 BICC1 SN+VEGFAab appears to overlap with figure S11b BICC1 SN LCN2ab -, BxPC-3. Figure S10b AsPC-1 BICC1 SN appears to overlap with figure S11b BICC1 SN LCN2ab -, AsPC-1. Figure S11c vector SN CXCL1ab - BxPC-3 appears to overlap with Figure S11d CFPAC-1 rhLCN2 30 min CXCL1ab -. Figure S4e furthest left mouse image for Pan02 shBICC1 appears to overlap with figure S12b furthest left mouse image for KPC vector. The Editors have lost confidence in the data and conclusions of this article. Author Shengyu Yang agrees with this retraction. All other authors did not respond to correspondence from the publisher regarding this retraction.

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UR - https://www.scopus.com/pages/publications/105026442358#tab=citedBy

U2 - 10.1038/s41392-025-02561-9

DO - 10.1038/s41392-025-02561-9

M3 - Comment/debate

C2 - 41484065

AN - SCOPUS:105026442358

SN - 2095-9907

VL - 11

JO - Signal Transduction and Targeted Therapy

JF - Signal Transduction and Targeted Therapy

IS - 1

M1 - 4

ER -

Retraction Note: BICC1 drives pancreatic cancer progression by inducing VEGF-independent angiogenesis(Signal Transduction and Targeted Therapy, 10.1038/s41392-023-01478-5)

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