Abstract
Graft-versus-host disease (GVHD) remains a major complication of bone marrow transplantation. This report describes reversal of GVHD by infusion of stored recipient bone marrow following combined liver-bone marrow allotransplantation. Graft-versus-host disease developed at the end of the first postoperative week. The skin involvement progressively spread to approximately 80% of the body surface and was not affected by modification of the immunosuppressive treatment. On the 42nd and 43rd postoperative day 1.23 × 108 and 1.6 × 108 autologous bone marrow cells per kg of recipient body weight were infused. The skin rush began to dramatically improve and resolved within 2 wk from the autologous marrow infusion. Autologous bone marrow storage previous to allogeneic bone marrow transplantation for tolerance induction could constitute a safety net in case of occurrence of GVHD.
Original language | English (US) |
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Pages (from-to) | 187-192 |
Number of pages | 6 |
Journal | Cell Transplantation |
Volume | 3 |
Issue number | 2 |
DOIs | |
State | Published - 1994 |
All Science Journal Classification (ASJC) codes
- Biomedical Engineering
- Cell Biology
- Transplantation