Reversal of graft-versus-host disease with infusion of autologous bone marrow

Camillo Ricordi; Anreas G. Tzakis; Adriana Zeevi; Witold B. Rybka; Anthony J. Demetris; Paulo A.C. Fontes; Michael A. Nalesnik; Massimo Trucco; Ferdinand O. Ukah; Edward D. Ball; Edward E. Mullen; Ignazio R. Marino; John J. Fung; Thomas E. Starzl

doi:10.1177/096368979400300207

Reversal of graft-versus-host disease with infusion of autologous bone marrow

Camillo Ricordi, Anreas G. Tzakis, Adriana Zeevi, Witold B. Rybka, Anthony J. Demetris, Paulo A.C. Fontes, Michael A. Nalesnik, Massimo Trucco, Ferdinand O. Ukah, Edward D. Ball, Edward E. Mullen, Ignazio R. Marino, John J. Fung, Thomas E. Starzl

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16 Scopus citations

Abstract

Graft-versus-host disease (GVHD) remains a major complication of bone marrow transplantation. This report describes reversal of GVHD by infusion of stored recipient bone marrow following combined liver-bone marrow allotransplantation. Graft-versus-host disease developed at the end of the first postoperative week. The skin involvement progressively spread to approximately 80% of the body surface and was not affected by modification of the immunosuppressive treatment. On the 42nd and 43rd postoperative day 1.23 × 10⁸ and 1.6 × 10⁸ autologous bone marrow cells per kg of recipient body weight were infused. The skin rush began to dramatically improve and resolved within 2 wk from the autologous marrow infusion. Autologous bone marrow storage previous to allogeneic bone marrow transplantation for tolerance induction could constitute a safety net in case of occurrence of GVHD.

Original language	English (US)
Pages (from-to)	187-192
Number of pages	6
Journal	Cell Transplantation
Volume	3
Issue number	2
DOIs	https://doi.org/10.1177/096368979400300207
State	Published - 1994

All Science Journal Classification (ASJC) codes

Biomedical Engineering
Cell Biology
Transplantation

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@article{7c235f7c2446418a8a69fb3b84d17720,

title = "Reversal of graft-versus-host disease with infusion of autologous bone marrow",

abstract = "Graft-versus-host disease (GVHD) remains a major complication of bone marrow transplantation. This report describes reversal of GVHD by infusion of stored recipient bone marrow following combined liver-bone marrow allotransplantation. Graft-versus-host disease developed at the end of the first postoperative week. The skin involvement progressively spread to approximately 80% of the body surface and was not affected by modification of the immunosuppressive treatment. On the 42nd and 43rd postoperative day 1.23 × 108 and 1.6 × 108 autologous bone marrow cells per kg of recipient body weight were infused. The skin rush began to dramatically improve and resolved within 2 wk from the autologous marrow infusion. Autologous bone marrow storage previous to allogeneic bone marrow transplantation for tolerance induction could constitute a safety net in case of occurrence of GVHD.",

author = "Camillo Ricordi and Tzakis, {Anreas G.} and Adriana Zeevi and Rybka, {Witold B.} and Demetris, {Anthony J.} and Fontes, {Paulo A.C.} and Nalesnik, {Michael A.} and Massimo Trucco and Ukah, {Ferdinand O.} and Ball, {Edward D.} and Mullen, {Edward E.} and Marino, {Ignazio R.} and Fung, {John J.} and Starzl, {Thomas E.}",

year = "1994",

doi = "10.1177/096368979400300207",

language = "English (US)",

volume = "3",

pages = "187--192",

journal = "Cell Transplantation",

issn = "0963-6897",

publisher = "Cognizant Communication Corporation",

number = "2",

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T1 - Reversal of graft-versus-host disease with infusion of autologous bone marrow

AU - Ricordi, Camillo

AU - Tzakis, Anreas G.

AU - Zeevi, Adriana

AU - Rybka, Witold B.

AU - Demetris, Anthony J.

AU - Fontes, Paulo A.C.

AU - Nalesnik, Michael A.

AU - Trucco, Massimo

AU - Ukah, Ferdinand O.

AU - Ball, Edward D.

AU - Mullen, Edward E.

AU - Marino, Ignazio R.

AU - Fung, John J.

AU - Starzl, Thomas E.

PY - 1994

Y1 - 1994

N2 - Graft-versus-host disease (GVHD) remains a major complication of bone marrow transplantation. This report describes reversal of GVHD by infusion of stored recipient bone marrow following combined liver-bone marrow allotransplantation. Graft-versus-host disease developed at the end of the first postoperative week. The skin involvement progressively spread to approximately 80% of the body surface and was not affected by modification of the immunosuppressive treatment. On the 42nd and 43rd postoperative day 1.23 × 108 and 1.6 × 108 autologous bone marrow cells per kg of recipient body weight were infused. The skin rush began to dramatically improve and resolved within 2 wk from the autologous marrow infusion. Autologous bone marrow storage previous to allogeneic bone marrow transplantation for tolerance induction could constitute a safety net in case of occurrence of GVHD.

AB - Graft-versus-host disease (GVHD) remains a major complication of bone marrow transplantation. This report describes reversal of GVHD by infusion of stored recipient bone marrow following combined liver-bone marrow allotransplantation. Graft-versus-host disease developed at the end of the first postoperative week. The skin involvement progressively spread to approximately 80% of the body surface and was not affected by modification of the immunosuppressive treatment. On the 42nd and 43rd postoperative day 1.23 × 108 and 1.6 × 108 autologous bone marrow cells per kg of recipient body weight were infused. The skin rush began to dramatically improve and resolved within 2 wk from the autologous marrow infusion. Autologous bone marrow storage previous to allogeneic bone marrow transplantation for tolerance induction could constitute a safety net in case of occurrence of GVHD.

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DO - 10.1177/096368979400300207

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JO - Cell Transplantation

JF - Cell Transplantation

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ER -

Reversal of graft-versus-host disease with infusion of autologous bone marrow

Abstract

All Science Journal Classification (ASJC) codes

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