Abstract
Irinotecan-induced gastrointestinal toxicities are common and typically present in the form of diarrhea or nausea and vomiting. However, severe hyperbilirubinemia (grade 3/4) has not been previously reported in association with this chemotherapeutic agent. We report a case of prolonged grade 4 hyperbilirubinemia after a single dose of irinotecan at 125 mg/m2. This severe toxicity was attributed to a UGT1A1 7/7 genotype and resolved to grade 2 after 8 weeks of supportive care. This case outlines the possibility of severe hepatic toxicity with moderate doses of irinotecan in patients with a UGT1A1 7/7 genotype. Despite the severity and prolonged duration of the associated irinotecan-induced hepatic toxicity, the management of similar cases should focus on intensive supportive measures because the toxicity is likely to resolve eventually.
Original language | English (US) |
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Pages (from-to) | 447-449 |
Number of pages | 3 |
Journal | Clinical Colorectal Cancer |
Volume | 6 |
Issue number | 6 |
DOIs | |
State | Published - Mar 2007 |
All Science Journal Classification (ASJC) codes
- Oncology
- Gastroenterology