TY - JOUR
T1 - Revisiting an old friend
T2 - new findings in alphavirus structure and assembly
AU - Button, Julie M.
AU - Qazi, Shefah A.
AU - Wang, Joseph Che Yen
AU - Mukhopadhyay, Suchetana
N1 - Funding Information:
We thank J. Jose, and R.J. Kuhn for providing Figure 2, H. Harrington for providing Figure 4, and our lab, collaborators, and members of the Indiana University Virology group for valuable discussions. We apologize to the colleagues whose contributions were not discussed or cited due to space constraints.
Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/12
Y1 - 2020/12
N2 - Alphaviruses are transmitted by an arthropod vector to a vertebrate host. The disease pathologies, cellular environments, immune responses, and host factors are very different in these organisms. Yet, the virus is able to infect, replicate, and assemble into new particles in these two animals using one set of genetic instructions. The balance between conserved mechanisms and unique strategies during virus assembly is critical for fitness of the virus. In this review, we discuss new findings in receptor binding, polyprotein topology, nucleocapsid core formation, and particle budding that have emerged in the last five years and share opinions on how these new findings might answer some questions regarding alphavirus structure and assembly.
AB - Alphaviruses are transmitted by an arthropod vector to a vertebrate host. The disease pathologies, cellular environments, immune responses, and host factors are very different in these organisms. Yet, the virus is able to infect, replicate, and assemble into new particles in these two animals using one set of genetic instructions. The balance between conserved mechanisms and unique strategies during virus assembly is critical for fitness of the virus. In this review, we discuss new findings in receptor binding, polyprotein topology, nucleocapsid core formation, and particle budding that have emerged in the last five years and share opinions on how these new findings might answer some questions regarding alphavirus structure and assembly.
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U2 - 10.1016/j.coviro.2020.06.005
DO - 10.1016/j.coviro.2020.06.005
M3 - Review article
C2 - 32683295
AN - SCOPUS:85087859732
SN - 1879-6257
VL - 45
SP - 25
EP - 33
JO - Current Opinion in Virology
JF - Current Opinion in Virology
ER -