TY - JOUR
T1 - Revisiting the Association Between Inflammatory Bowel Disease and Parkinson's Disease
AU - Coates, Matthew D.
AU - Ba, Djibril M.
AU - Liu, Guodong
AU - Dalessio, Shannon
AU - Leslie, Douglas L.
AU - Huang, Xuemei
N1 - Publisher Copyright:
© 2021 The Author(s). Published by Oxford University Press on behalf of Crohn's & Colitis Foundation. All rights reserved. For permissions, please e-mail: [email protected].
PY - 2022/6/1
Y1 - 2022/6/1
N2 - Background: Several studies have reported an association between inflammatory bowel disease (IBD) and Parkinson's disease (PD). The aim of this study is to re-evaluate for an association between IBD and PD while controlling for potential socioeconomic and environmental confounders. Methods: We performed a retrospective cohort study using the Truven Health Marketscan database between January 1, 2005, and December 31, 2014. Individuals with IBD and household age-matched controls were identified. Adjusted hazard ratios (HRs) were calculated for the development of incident PD, adjusting for age, sex, residence type, US region, comorbidities, and behavior. Results: In all, 154 051 subjects with IBD and an equal number of controls were identified. During a mean (SD) follow-up of 3.8 (2.2) years, 132 incident PD cases were identified. There was no significant association between IBD and PD (adjusted HR, 1.01; 0.72-1.42) when adjusting for the confounders previously mentioned. Conclusions: We found no statistically significant association between these disorders. It is possible that previous associations identified between these disorders were confounded by environmental and socioeconomic factors.
AB - Background: Several studies have reported an association between inflammatory bowel disease (IBD) and Parkinson's disease (PD). The aim of this study is to re-evaluate for an association between IBD and PD while controlling for potential socioeconomic and environmental confounders. Methods: We performed a retrospective cohort study using the Truven Health Marketscan database between January 1, 2005, and December 31, 2014. Individuals with IBD and household age-matched controls were identified. Adjusted hazard ratios (HRs) were calculated for the development of incident PD, adjusting for age, sex, residence type, US region, comorbidities, and behavior. Results: In all, 154 051 subjects with IBD and an equal number of controls were identified. During a mean (SD) follow-up of 3.8 (2.2) years, 132 incident PD cases were identified. There was no significant association between IBD and PD (adjusted HR, 1.01; 0.72-1.42) when adjusting for the confounders previously mentioned. Conclusions: We found no statistically significant association between these disorders. It is possible that previous associations identified between these disorders were confounded by environmental and socioeconomic factors.
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U2 - 10.1093/ibd/izab175
DO - 10.1093/ibd/izab175
M3 - Article
C2 - 34259840
AN - SCOPUS:85129859270
SN - 1078-0998
VL - 28
SP - 850
EP - 854
JO - Inflammatory bowel diseases
JF - Inflammatory bowel diseases
IS - 6
ER -