TY - JOUR
T1 - Ribosome dependence of persister cell formation and resuscitation
AU - Wood, Thomas K.
AU - Song, Sooyeon
AU - Yamasaki, Ryota
N1 - Publisher Copyright:
© 2019, The Microbiological Society of Korea.
PY - 2019/3/1
Y1 - 2019/3/1
N2 - Since most bacterial cells are starving, they must enter a resting stage. Persister is the term used for metabolically-dormant cells that are not spores, and these cells arise from stress such as that from antibiotics as well as that from starvation. Because of their lack of metabolism, persister cells survive exposure to multiple stresses without undergoing genetic change; i.e., they have no inherited phenotype and behave as wild-type cells once the stress is removed and nutrients are presented. In contrast, mutations allow resistant bacteria to grow in the presence of antibiotics and slow growth allows tolerant cells to withstand higher concentrations of antibiotics; hence, there are three closely-related phenotypes: persistent, resistant, and tolerant. In addition, since dormancy is so prevalent, persister cells must have a means for resuscitating (since so many cells should obtain this resting state). In this review, we focus on what is known about the formation and resuscitation of persister cells.
AB - Since most bacterial cells are starving, they must enter a resting stage. Persister is the term used for metabolically-dormant cells that are not spores, and these cells arise from stress such as that from antibiotics as well as that from starvation. Because of their lack of metabolism, persister cells survive exposure to multiple stresses without undergoing genetic change; i.e., they have no inherited phenotype and behave as wild-type cells once the stress is removed and nutrients are presented. In contrast, mutations allow resistant bacteria to grow in the presence of antibiotics and slow growth allows tolerant cells to withstand higher concentrations of antibiotics; hence, there are three closely-related phenotypes: persistent, resistant, and tolerant. In addition, since dormancy is so prevalent, persister cells must have a means for resuscitating (since so many cells should obtain this resting state). In this review, we focus on what is known about the formation and resuscitation of persister cells.
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U2 - 10.1007/s12275-019-8629-2
DO - 10.1007/s12275-019-8629-2
M3 - Review article
C2 - 30806978
AN - SCOPUS:85062101792
SN - 1225-8873
VL - 57
SP - 213
EP - 219
JO - Journal of Microbiology
JF - Journal of Microbiology
IS - 3
ER -