TY - JOUR
T1 - Rifampin Use and Safety in Hospitalized Infants
AU - Arnold, Christopher J.
AU - Ericson, Jessica
AU - Kohman, Jordan
AU - Corey, Kaitlyn L.
AU - Oh, Morgan
AU - Onabanjo, Janet
AU - Hornik, Christoph P.
AU - Clark, Reese H.
AU - Benjamin, Daniel K.
AU - Smith, P. Brian
AU - Chu, Vivian H.
N1 - Publisher Copyright:
©2015 by Thieme Medical Publishers, Inc., 333 Seventh Avenue,New York, NY 10001, USA.
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Objective This study aims to examine the use and safety of rifampin in the hospitalized infants. Study Design Observational study of clinical and laboratory adverse events among infants exposed to rifampin from 348 neonatal intensive care units managed by the Pediatrix Medical Group between 1997 and 2012. Result Overall, 2,500 infants received 4,279 courses of rifampin; mean gestational age was 27 weeks (5th, 95th percentile; 23, 36) and mean birth weight was 1,125g (515; 2,830). Thrombocytopenia (121/1,000 infant days) and conjugated hyperbilirubinemia (25/1,000 infant days) were the most common laboratory adverse events. The most common clinical adverse events were medical necrotizing enterocolitis (64/2,500 infants, 3%) and seizure (60/2,500 infants, 2%). Conclusion The overall incidence of adverse events among infants receiving rifampin appears low; however, additional studies to further evaluate safety and dosing of rifampin in this population are needed.
AB - Objective This study aims to examine the use and safety of rifampin in the hospitalized infants. Study Design Observational study of clinical and laboratory adverse events among infants exposed to rifampin from 348 neonatal intensive care units managed by the Pediatrix Medical Group between 1997 and 2012. Result Overall, 2,500 infants received 4,279 courses of rifampin; mean gestational age was 27 weeks (5th, 95th percentile; 23, 36) and mean birth weight was 1,125g (515; 2,830). Thrombocytopenia (121/1,000 infant days) and conjugated hyperbilirubinemia (25/1,000 infant days) were the most common laboratory adverse events. The most common clinical adverse events were medical necrotizing enterocolitis (64/2,500 infants, 3%) and seizure (60/2,500 infants, 2%). Conclusion The overall incidence of adverse events among infants receiving rifampin appears low; however, additional studies to further evaluate safety and dosing of rifampin in this population are needed.
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U2 - 10.1055/s-0034-1543955
DO - 10.1055/s-0034-1543955
M3 - Article
C2 - 25594217
AN - SCOPUS:84929326729
SN - 0735-1631
VL - 32
SP - 565
EP - 570
JO - American Journal of Perinatology
JF - American Journal of Perinatology
IS - 6
ER -