Ring opening of 3-bromo-2-isoxazolines to β-hydroxy nitriles

Martin G. Kociolek; Kyle P. Kalbarczyk

doi:10.1081/SCC-200039452

Ring opening of 3-bromo-2-isoxazolines to β-hydroxy nitriles

Martin G. Kociolek
, Kyle P. Kalbarczyk

School of Science (Behrend)

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

3-Bromo-2-isoxazolines were converted to the corresponding β-hydroxy nitriles by treatment with sodium iodide in the presence of either chlorotrimethylsilane or para-toluenesulfonic acid. Both methods gave β-hydroxy nitriles under relatively mild conditions in good to moderate yields for a variety of substituted 3-bromo-2-isoxazolines.

Original language	English (US)
Pages (from-to)	4387-4394
Number of pages	8
Journal	Synthetic Communications
Volume	34
Issue number	23
DOIs	https://doi.org/10.1081/SCC-200039452
State	Published - 2004

All Science Journal Classification (ASJC) codes

Organic Chemistry

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10.1081/SCC-200039452

Cite this

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title = "Ring opening of 3-bromo-2-isoxazolines to β-hydroxy nitriles",

abstract = "3-Bromo-2-isoxazolines were converted to the corresponding β-hydroxy nitriles by treatment with sodium iodide in the presence of either chlorotrimethylsilane or para-toluenesulfonic acid. Both methods gave β-hydroxy nitriles under relatively mild conditions in good to moderate yields for a variety of substituted 3-bromo-2-isoxazolines.",

author = "Kociolek, \{Martin G.\} and Kalbarczyk, \{Kyle P.\}",

year = "2004",

doi = "10.1081/SCC-200039452",

language = "English (US)",

volume = "34",

pages = "4387--4394",

journal = "Synthetic Communications",

issn = "0039-7911",

publisher = "Taylor and Francis Ltd.",

number = "23",

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T1 - Ring opening of 3-bromo-2-isoxazolines to β-hydroxy nitriles

AU - Kociolek, Martin G.

AU - Kalbarczyk, Kyle P.

PY - 2004

Y1 - 2004

N2 - 3-Bromo-2-isoxazolines were converted to the corresponding β-hydroxy nitriles by treatment with sodium iodide in the presence of either chlorotrimethylsilane or para-toluenesulfonic acid. Both methods gave β-hydroxy nitriles under relatively mild conditions in good to moderate yields for a variety of substituted 3-bromo-2-isoxazolines.

AB - 3-Bromo-2-isoxazolines were converted to the corresponding β-hydroxy nitriles by treatment with sodium iodide in the presence of either chlorotrimethylsilane or para-toluenesulfonic acid. Both methods gave β-hydroxy nitriles under relatively mild conditions in good to moderate yields for a variety of substituted 3-bromo-2-isoxazolines.

UR - https://www.scopus.com/pages/publications/10644278759

UR - https://www.scopus.com/pages/publications/10644278759#tab=citedBy

U2 - 10.1081/SCC-200039452

DO - 10.1081/SCC-200039452

M3 - Article

AN - SCOPUS:10644278759

SN - 0039-7911

VL - 34

SP - 4387

EP - 4394

JO - Synthetic Communications

JF - Synthetic Communications

IS - 23

ER -

Ring opening of 3-bromo-2-isoxazolines to β-hydroxy nitriles

Abstract

All Science Journal Classification (ASJC) codes

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