Risk and factors determining diabetes after mild, nonnecrotizing acute pancreatitis

Ariana Pichardo-Lowden, Mark O. Goodarzi, Guru Trikudanathan, Jose Serrano, Kathleen M. Dungan

Research output: Contribution to journalReview articlepeer-review

Abstract

Purpose of reviewDiabetes mellitus (DM) is relatively common following acute pancreatitis (AP), even after mild acute pancreatitis (MAP), the most frequent AP presentation, in which there is no overt beta cell injury. Post-AP related diabetes is widely misdiagnosed, resulting in potentially inappropriate treatment and worse outcomes than type 2 diabetes (T2D). Thus, it is important to understand risk across the spectrum of AP severity.Recent findingsBiological mechanisms are unclear and may include local and systemic inflammation leading to beta cell dysfunction and insulin resistance, altered gut barrier and/or gut peptides and possibly islet autoimmunity, though no studies have specifically focused on MAP. While studies examining clinical risk factors on MAP exclusively are lacking, there are studies which include MAP. These studies vary in scientific rigor, approaches to rule out preexisting diabetes, variable AP severity, diagnostic testing methods, and duration of follow-up. Overall, disease related factors, including AP severity, as well as established T2D risk factors are reported to contribute to the risk for DM following AP.SummaryThough numerous studies have explored risk factors for DM after AP, few studies specifically focused on MAP, highlighting a key knowledge gap that is relevant to the majority of patients with AP.

Original languageEnglish (US)
Pages (from-to)396-403
Number of pages8
JournalCurrent Opinion in Gastroenterology
Volume40
Issue number5
DOIs
StatePublished - Sep 1 2024

All Science Journal Classification (ASJC) codes

  • Gastroenterology

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