TY - JOUR
T1 - Risk-benefit analysis of the association of ambient fine particulate matter pollution and physical activity with age-related cataract
T2 - A prospective cohort study
AU - Wu, Yinglin
AU - Xie, Chuanbo
AU - Qian, Zhengmin (Min)
AU - Lin, Haotian
AU - McMillin, Stephen Edward
AU - Vaughn, Michael G.
AU - Ruan, Zengliang
AU - Li, Haitao
AU - Lin, Hualiang
AU - Hu, Qiansheng
AU - Zhang, Zilong
N1 - Publisher Copyright:
© 2022 Turkish National Committee for Air Pollution Research and Control
PY - 2022/11
Y1 - 2022/11
N2 - The aim of this study was to examine the associations of fine particulate matter (PM2.5) and physical activity (PA) with age-related cataract and its subtypes, and to explore potential interactions between PM2.5 and PA. A total of 291,627 participants enrolled in the UK Biobank cohort during 2006–2010 was included. The annual mean concentration of PM2.5 at each participant's residential address was estimated using Land Use Regression models. PA was measured using the International Physical Activity Questionnaire. Cox proportional hazards model was used to examine the associations of PM2.5 and PA with incident age-related cataract, and to assess their interactions on additive and multiplicative scales. We identified 12,826 incident cases of age-related cataract, including 7686 cases of nuclear cataract and 5140 cases of non-nuclear cataract. Higher PM2.5 exposure was associated with a higher risk of age-related cataract [HR = 1.140; 95% CI: 1.105, 1.177; per 1 μg/m3 increase], and the association was stronger for non-nuclear cataract than for nuclear cataract. There was a negative association between PA and cataract [HR = 0.925; 95% CI: 0.879, 0.974; comparing high to low level]. No clear evidence of the interactions between PM2.5 and PA was found. Our findings indicated that high PM2.5 exposure and low levels of PA were independently associated with increased risks of incident age-related cataract.
AB - The aim of this study was to examine the associations of fine particulate matter (PM2.5) and physical activity (PA) with age-related cataract and its subtypes, and to explore potential interactions between PM2.5 and PA. A total of 291,627 participants enrolled in the UK Biobank cohort during 2006–2010 was included. The annual mean concentration of PM2.5 at each participant's residential address was estimated using Land Use Regression models. PA was measured using the International Physical Activity Questionnaire. Cox proportional hazards model was used to examine the associations of PM2.5 and PA with incident age-related cataract, and to assess their interactions on additive and multiplicative scales. We identified 12,826 incident cases of age-related cataract, including 7686 cases of nuclear cataract and 5140 cases of non-nuclear cataract. Higher PM2.5 exposure was associated with a higher risk of age-related cataract [HR = 1.140; 95% CI: 1.105, 1.177; per 1 μg/m3 increase], and the association was stronger for non-nuclear cataract than for nuclear cataract. There was a negative association between PA and cataract [HR = 0.925; 95% CI: 0.879, 0.974; comparing high to low level]. No clear evidence of the interactions between PM2.5 and PA was found. Our findings indicated that high PM2.5 exposure and low levels of PA were independently associated with increased risks of incident age-related cataract.
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U2 - 10.1016/j.apr.2022.101578
DO - 10.1016/j.apr.2022.101578
M3 - Article
AN - SCOPUS:85140096755
SN - 1309-1042
VL - 13
JO - Atmospheric Pollution Research
JF - Atmospheric Pollution Research
IS - 11
M1 - 101578
ER -