TY - JOUR
T1 - Risk factors for melioidosis in Udupi District, Karnataka, India, January 2017-July 2018
AU - Singh, Akhileshwar
AU - Talyan, Ashok
AU - Chandra, Ramesh
AU - Srivastav, Anubhav
AU - Upadhya, Vasudeva
AU - Mukhopadhyay, Chiranjay
AU - Shreedhar, Shyamsundar
AU - Sudhakaran, Deepak
AU - Nair, Suma
AU - Papanna, Mohan
AU - Yadav, Rajesh
AU - Singh, Sujeet Kumar
AU - Dikid, Tanzin
N1 - Publisher Copyright:
This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
PY - 2022/12
Y1 - 2022/12
N2 - We initiated an epidemiological investigation following the death of a previously healthy 17 year-old boy with neuro-melioidosis. A case was defined as a culture-confirmed melioidosis patient from Udupi district admitted to hospital A from January 2013—July 2018. For the case control study, we enrolled a subset of cases admitted to hospital A from January 2017-July 2018. A control was resident of Udupi district admitted to hospital A in July 2018 with a non-infectious condition. Using a matched case-control design, we compared each case to 3 controls using age and sex groups. We assessed for risk factors related to water storage, activities of daily living, injuries and environmental exposures (three months prior to hospitalization), using conditional regression analysis. We identified 50 cases with case fatality rate 16%. Uncontrolled diabetes mellitus was present in 84% cases and 66% of cases occurred between May and October (rainy season). Percutaneous inoculation through exposure to stagnant water and injury leading to breakage in the skin were identified as an important mode of transmission. We used these findings to develop a surveillance case definition and initiated training of the district laboratory for melioidosis diagnosis.
AB - We initiated an epidemiological investigation following the death of a previously healthy 17 year-old boy with neuro-melioidosis. A case was defined as a culture-confirmed melioidosis patient from Udupi district admitted to hospital A from January 2013—July 2018. For the case control study, we enrolled a subset of cases admitted to hospital A from January 2017-July 2018. A control was resident of Udupi district admitted to hospital A in July 2018 with a non-infectious condition. Using a matched case-control design, we compared each case to 3 controls using age and sex groups. We assessed for risk factors related to water storage, activities of daily living, injuries and environmental exposures (three months prior to hospitalization), using conditional regression analysis. We identified 50 cases with case fatality rate 16%. Uncontrolled diabetes mellitus was present in 84% cases and 66% of cases occurred between May and October (rainy season). Percutaneous inoculation through exposure to stagnant water and injury leading to breakage in the skin were identified as an important mode of transmission. We used these findings to develop a surveillance case definition and initiated training of the district laboratory for melioidosis diagnosis.
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U2 - 10.1371/journal.pgph.0000865
DO - 10.1371/journal.pgph.0000865
M3 - Article
AN - SCOPUS:85195320929
SN - 2767-3375
VL - 2
JO - PLOS Global Public Health
JF - PLOS Global Public Health
IS - 12
M1 - e0000865
ER -
