TY - JOUR
T1 - RNA Binding Proteins as Potential Therapeutic Targets in Colorectal Cancer
AU - Singh, Vikash
AU - Singh, Amandeep
AU - Liu, Alvin John
AU - Fuchs, Serge Y.
AU - Sharma, Arun
AU - Spiegelman, Vladimir S.
N1 - Publisher Copyright:
© 2024 by the authors.
PY - 2024/10
Y1 - 2024/10
N2 - RNA-binding proteins (RBPs) are crucial in regulating gene expression in the intestine, and their abnormal activity can lead to colorectal cancer (CRC). This review explores how specific RBPs, such as LIN28, IGF2BPs, Musashi, HuR, and CELF1, contribute to CRC by affecting the stability and translation of key cancer-related genes. These proteins can promote tumor growth, spread, and resistance to treatments. Although targeting RBPs is challenging, recently discovered small molecules can disrupt the harmful interactions, showing promise for new CRC therapies. Further research and development of RBP-targeting agents should lead to better treatment options for CRC patients.
AB - RNA-binding proteins (RBPs) are crucial in regulating gene expression in the intestine, and their abnormal activity can lead to colorectal cancer (CRC). This review explores how specific RBPs, such as LIN28, IGF2BPs, Musashi, HuR, and CELF1, contribute to CRC by affecting the stability and translation of key cancer-related genes. These proteins can promote tumor growth, spread, and resistance to treatments. Although targeting RBPs is challenging, recently discovered small molecules can disrupt the harmful interactions, showing promise for new CRC therapies. Further research and development of RBP-targeting agents should lead to better treatment options for CRC patients.
UR - https://www.scopus.com/pages/publications/85207649271
UR - https://www.scopus.com/inward/citedby.url?scp=85207649271&partnerID=8YFLogxK
U2 - 10.3390/cancers16203502
DO - 10.3390/cancers16203502
M3 - Review article
C2 - 39456596
AN - SCOPUS:85207649271
SN - 2072-6694
VL - 16
JO - Cancers
JF - Cancers
IS - 20
M1 - 3502
ER -
