RNA-guided genome editing à la carte

Philippe Horvath; Rodolphe Barrangou

doi:10.1038/cr.2013.39

RNA-guided genome editing à la carte

Philippe Horvath, Rodolphe Barrangou

Food Science

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Two recent papers in Science illustrate how the prokaryotic CRISPR-Cas immune system machinery, which typically targets invasive genetic elements such as viruses and plasmids, can be converted into a sophisticated molecular tool for next-generation human genome editing. The versatile Cas9 RNA-guided endonuclease can be readily reprogrammed using customizable small RNAs for sequence-specific single- or double-stranded DNA cleavage.

Original language	English (US)
Pages (from-to)	733-734
Number of pages	2
Journal	Cell Research
Volume	23
Issue number	6
DOIs	https://doi.org/10.1038/cr.2013.39
State	Published - Jun 2013

All Science Journal Classification (ASJC) codes

Molecular Biology
Cell Biology

Access to Document

10.1038/cr.2013.39

Cite this

@article{3192c2cccb9349838877be24e47af018,

title = "RNA-guided genome editing {\`a} la carte",

abstract = "Two recent papers in Science illustrate how the prokaryotic CRISPR-Cas immune system machinery, which typically targets invasive genetic elements such as viruses and plasmids, can be converted into a sophisticated molecular tool for next-generation human genome editing. The versatile Cas9 RNA-guided endonuclease can be readily reprogrammed using customizable small RNAs for sequence-specific single- or double-stranded DNA cleavage.",

author = "Philippe Horvath and Rodolphe Barrangou",

year = "2013",

month = jun,

doi = "10.1038/cr.2013.39",

language = "English (US)",

volume = "23",

pages = "733--734",

journal = "Cell Research",

issn = "1001-0602",

publisher = "Nature Publishing Group",

number = "6",

}

TY - JOUR

T1 - RNA-guided genome editing à la carte

AU - Horvath, Philippe

AU - Barrangou, Rodolphe

PY - 2013/6

Y1 - 2013/6

N2 - Two recent papers in Science illustrate how the prokaryotic CRISPR-Cas immune system machinery, which typically targets invasive genetic elements such as viruses and plasmids, can be converted into a sophisticated molecular tool for next-generation human genome editing. The versatile Cas9 RNA-guided endonuclease can be readily reprogrammed using customizable small RNAs for sequence-specific single- or double-stranded DNA cleavage.

AB - Two recent papers in Science illustrate how the prokaryotic CRISPR-Cas immune system machinery, which typically targets invasive genetic elements such as viruses and plasmids, can be converted into a sophisticated molecular tool for next-generation human genome editing. The versatile Cas9 RNA-guided endonuclease can be readily reprogrammed using customizable small RNAs for sequence-specific single- or double-stranded DNA cleavage.

UR - http://www.scopus.com/inward/record.url?scp=84878693246&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878693246&partnerID=8YFLogxK

U2 - 10.1038/cr.2013.39

DO - 10.1038/cr.2013.39

M3 - Article

C2 - 23478298

AN - SCOPUS:84878693246

SN - 1001-0602

VL - 23

SP - 733

EP - 734

JO - Cell Research

JF - Cell Research

IS - 6

ER -

RNA-guided genome editing à la carte

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this