RNA-guided genome editing à la carte

Philippe Horvath; Rodolphe Barrangou

doi:10.1038/cr.2013.39

RNA-guided genome editing à la carte

Philippe Horvath, Rodolphe Barrangou

Food Science

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Two recent papers in Science illustrate how the prokaryotic CRISPR-Cas immune system machinery, which typically targets invasive genetic elements such as viruses and plasmids, can be converted into a sophisticated molecular tool for next-generation human genome editing. The versatile Cas9 RNA-guided endonuclease can be readily reprogrammed using customizable small RNAs for sequence-specific single- or double-stranded DNA cleavage.

Original language	English (US)
Pages (from-to)	733-734
Number of pages	2
Journal	Cell Research
Volume	23
Issue number	6
DOIs	https://doi.org/10.1038/cr.2013.39
State	Published - Jun 2013

All Science Journal Classification (ASJC) codes

Molecular Biology
Cell Biology

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10.1038/cr.2013.39

Cite this

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abstract = "Two recent papers in Science illustrate how the prokaryotic CRISPR-Cas immune system machinery, which typically targets invasive genetic elements such as viruses and plasmids, can be converted into a sophisticated molecular tool for next-generation human genome editing. The versatile Cas9 RNA-guided endonuclease can be readily reprogrammed using customizable small RNAs for sequence-specific single- or double-stranded DNA cleavage.",

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RNA-guided genome editing à la carte

Abstract

All Science Journal Classification (ASJC) codes

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