TY - JOUR
T1 - Roadmap and standard operating procedures for biobanking and discovery of neurochemical markers in ALS
AU - Otto, Markus
AU - Bowser, Robert
AU - Turner, Martin
AU - Berry, James
AU - Brettschneider, Johannes
AU - Connor, James
AU - Costa, Jlia
AU - Cudkowicz, Merit
AU - Glass, Jonathan
AU - Jahn, Olaf
AU - Lehnert, Stefan
AU - Malaspina, Andrea
AU - Parnetti, Lucilla
AU - Petzold, Axel
AU - Shaw, Pamela
AU - Sherman, Alexander
AU - Steinacker, Petra
AU - Sßmuth, Sigurd
AU - Teunissen, Charlotte
AU - Tumani, Hayrettin
AU - Wuolikainen, Anna
AU - Ludolph, Albert
N1 - Funding Information:
This work was supported by World Federation of Neurology. The name Volcano Group was chosen because the first meeting of the group had to be postponed as several group members were stranded somewhere in the world because of the eruption of the Eyjafjallaj ö kull in Iceland in April 2010.
PY - 2012/1
Y1 - 2012/1
N2 - Despite major advances in deciphering the neuropathological hallmarks of amyotrophic lateral sclerosis (ALS), validated neurochemical biomarkers for monitoring disease activity, earlier diagnosis, defining prognosis and unlocking key pathophysiological pathways are lacking. Although several candidate biomarkers exist, translation into clinical application is hindered by small sample numbers, especially longitudinal, for independent verification. This review considers the potential routes to the discovery of neurochemical markers in ALS, and provides a consensus statement on standard operating procedures that will facilitate multicenter collaboration, validation and ultimately clinical translation.
AB - Despite major advances in deciphering the neuropathological hallmarks of amyotrophic lateral sclerosis (ALS), validated neurochemical biomarkers for monitoring disease activity, earlier diagnosis, defining prognosis and unlocking key pathophysiological pathways are lacking. Although several candidate biomarkers exist, translation into clinical application is hindered by small sample numbers, especially longitudinal, for independent verification. This review considers the potential routes to the discovery of neurochemical markers in ALS, and provides a consensus statement on standard operating procedures that will facilitate multicenter collaboration, validation and ultimately clinical translation.
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U2 - 10.3109/17482968.2011.627589
DO - 10.3109/17482968.2011.627589
M3 - Review article
C2 - 22214350
AN - SCOPUS:84855410186
SN - 1748-2968
VL - 13
SP - 1
EP - 10
JO - Amyotrophic Lateral Sclerosis
JF - Amyotrophic Lateral Sclerosis
IS - 1
ER -