Role of helix-loop-helix proteins during differentiation of erythroid cells

Archana Anantharaman; I. Ju Lin; Joeva Barrow; Shermi Y. Liang; Jude Masannat; John Strouboulis; Suming Huang; Jörg Bungert

doi:10.1128/MCB.01186-10

Role of helix-loop-helix proteins during differentiation of erythroid cells

Archana Anantharaman, I. Ju Lin, Joeva Barrow, Shermi Y. Liang, Jude Masannat, John Strouboulis, Suming Huang, Jörg Bungert

Research output: Contribution to journal › Review article › peer-review

39 Scopus citations

Abstract

Helix-loop-helix (HLH) proteins play a profound role in the process of development and cellular differentiation. Among the HLH proteins expressed in differentiating erythroid cells are the ubiquitous proteins Myc, USF1, USF2, and TFII-I, as well as the hematopoiesis-specific transcription factor Tal1/SCL. All of these HLH proteins exhibit distinct functions during the differentiation of erythroid cells. For example, Myc stimulates the proliferation of erythroid progenitor cells, while the USF proteins and Tal1 regulate genes that specify the differentiated phenotype. This minireview summarizes the known activities of Myc, USF, TFII-I, and Tal11/SCL and discusses how they may function sequentially, cooperatively, or antagonistically in regulating expression programs during the differentiation of erythroid cells.

Original language	English (US)
Pages (from-to)	1332-1343
Number of pages	12
Journal	Molecular and cellular biology
Volume	31
Issue number	7
DOIs	https://doi.org/10.1128/MCB.01186-10
State	Published - Apr 2011

All Science Journal Classification (ASJC) codes

Molecular Biology
Cell Biology

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10.1128/MCB.01186-10

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title = "Role of helix-loop-helix proteins during differentiation of erythroid cells",

abstract = "Helix-loop-helix (HLH) proteins play a profound role in the process of development and cellular differentiation. Among the HLH proteins expressed in differentiating erythroid cells are the ubiquitous proteins Myc, USF1, USF2, and TFII-I, as well as the hematopoiesis-specific transcription factor Tal1/SCL. All of these HLH proteins exhibit distinct functions during the differentiation of erythroid cells. For example, Myc stimulates the proliferation of erythroid progenitor cells, while the USF proteins and Tal1 regulate genes that specify the differentiated phenotype. This minireview summarizes the known activities of Myc, USF, TFII-I, and Tal11/SCL and discusses how they may function sequentially, cooperatively, or antagonistically in regulating expression programs during the differentiation of erythroid cells.",

author = "Archana Anantharaman and Lin, {I. Ju} and Joeva Barrow and Liang, {Shermi Y.} and Jude Masannat and John Strouboulis and Suming Huang and J{\"o}rg Bungert",

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AU - Anantharaman, Archana

AU - Lin, I. Ju

AU - Barrow, Joeva

AU - Liang, Shermi Y.

AU - Masannat, Jude

AU - Strouboulis, John

AU - Huang, Suming

AU - Bungert, Jörg

PY - 2011/4

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AB - Helix-loop-helix (HLH) proteins play a profound role in the process of development and cellular differentiation. Among the HLH proteins expressed in differentiating erythroid cells are the ubiquitous proteins Myc, USF1, USF2, and TFII-I, as well as the hematopoiesis-specific transcription factor Tal1/SCL. All of these HLH proteins exhibit distinct functions during the differentiation of erythroid cells. For example, Myc stimulates the proliferation of erythroid progenitor cells, while the USF proteins and Tal1 regulate genes that specify the differentiated phenotype. This minireview summarizes the known activities of Myc, USF, TFII-I, and Tal11/SCL and discusses how they may function sequentially, cooperatively, or antagonistically in regulating expression programs during the differentiation of erythroid cells.

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Role of helix-loop-helix proteins during differentiation of erythroid cells

Abstract

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