TY - JOUR
T1 - Role of Matrix Metalloproteinase Inhibitors in Preventing Abdominal Aortic Aneurysm
AU - Aziz, Faisal
AU - Kuivaniemi, Helena
PY - 2007/5
Y1 - 2007/5
N2 - Abdominal aortic aneurysm (AAA) is a significant health problem in the United States, with approximately 30,000 repair operations annually. Treatment of AAA is associated with more than 150,000 hospital admissions per year. The development of AAA is characterized by destruction of the elastic media of the aortic wall. A large body of evidence suggests that a group of enzymes called matrix metalloproteinases (MMPs) plays a significant role in the destruction of extracellular matrix in the aortic wall. MMP inhibition has, therefore, been viewed as an alternative pharmacotherapeutic approach to slow down the development and progression of small AAAs, thus reducing the need for surgical intervention.
AB - Abdominal aortic aneurysm (AAA) is a significant health problem in the United States, with approximately 30,000 repair operations annually. Treatment of AAA is associated with more than 150,000 hospital admissions per year. The development of AAA is characterized by destruction of the elastic media of the aortic wall. A large body of evidence suggests that a group of enzymes called matrix metalloproteinases (MMPs) plays a significant role in the destruction of extracellular matrix in the aortic wall. MMP inhibition has, therefore, been viewed as an alternative pharmacotherapeutic approach to slow down the development and progression of small AAAs, thus reducing the need for surgical intervention.
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U2 - 10.1016/j.avsg.2006.11.001
DO - 10.1016/j.avsg.2006.11.001
M3 - Review article
C2 - 17484978
AN - SCOPUS:34247581734
SN - 0890-5096
VL - 21
SP - 392
EP - 401
JO - Annals of Vascular Surgery
JF - Annals of Vascular Surgery
IS - 3
ER -