Role of Pituitary Hormones in the Growth of Human Breast Cancer

Olof H. Pearson, Andrea Manni, Mark Chambers, Jerald Brodkey, James S. Marshall

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Hypophysectomy was performed in 28 women with Stage IV breast cancer who were treated initially with antiestrogens. Six of 13 patients who responded to tamoxifen and 2 of 12 who failed to benefit from tamoxifen obtained remissions from hypophysectomy. The remissions average 11+ months. Three of 8 patients treated initially with antiestrogens have responded to androgen therapy. The results suggest that hormones other than estrogen, which appears to play a major role, may be involved in stimulating the growth of some human breast cancers. Prolactin receptors were detectable in 51% of human breast cancers and were detected in both estrogen receptor-positive and-negative tumors. Preliminary clinical correlations suggest that prolactin receptors will not be useful in predicting response to antiestrogen therapy.

Original languageEnglish (US)
Pages (from-to)4323-4326
Number of pages4
JournalCancer Research
StatePublished - Nov 1978

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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