Role of specific microRNAs for endothelial function and angiogenesis

Fusheng Wu, Zeran Yang, Guohong Li

Research output: Contribution to journalShort surveypeer-review

128 Scopus citations


Accumulating evidence indicates that various aspects of angiogenesis, such as proliferation, migration, and morphogenesis of endothelial cells, can be regulated by specific miRNAs in an endothelial-specific manner. As novel molecular targets, miRNAs have a potential value for treatment of angiogenesis-associated diseases such as cancers, inflammation, and vascular diseases. In this article, we review the latest advances in the identification and validation of angiogenesis-regulatory miRNAs and their targets, and discuss their roles and mechanisms in regulating endothelial cell function and angiogenesis.

Original languageEnglish (US)
Pages (from-to)549-553
Number of pages5
JournalBiochemical and Biophysical Research Communications
Issue number4
StatePublished - Sep 4 2009

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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