TY - JOUR
T1 - Role of specific microRNAs for endothelial function and angiogenesis
AU - Wu, Fusheng
AU - Yang, Zeran
AU - Li, Guohong
N1 - Funding Information:
The work was supported by the National 863 Program of China (Grant No. 2008AA02Z109, Dr. Wu) and by National Institutes of Health Grant HL087990 (Dr. Li).
PY - 2009/9/4
Y1 - 2009/9/4
N2 - Accumulating evidence indicates that various aspects of angiogenesis, such as proliferation, migration, and morphogenesis of endothelial cells, can be regulated by specific miRNAs in an endothelial-specific manner. As novel molecular targets, miRNAs have a potential value for treatment of angiogenesis-associated diseases such as cancers, inflammation, and vascular diseases. In this article, we review the latest advances in the identification and validation of angiogenesis-regulatory miRNAs and their targets, and discuss their roles and mechanisms in regulating endothelial cell function and angiogenesis.
AB - Accumulating evidence indicates that various aspects of angiogenesis, such as proliferation, migration, and morphogenesis of endothelial cells, can be regulated by specific miRNAs in an endothelial-specific manner. As novel molecular targets, miRNAs have a potential value for treatment of angiogenesis-associated diseases such as cancers, inflammation, and vascular diseases. In this article, we review the latest advances in the identification and validation of angiogenesis-regulatory miRNAs and their targets, and discuss their roles and mechanisms in regulating endothelial cell function and angiogenesis.
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U2 - 10.1016/j.bbrc.2009.06.075
DO - 10.1016/j.bbrc.2009.06.075
M3 - Short survey
C2 - 19540203
AN - SCOPUS:67650474075
SN - 0006-291X
VL - 386
SP - 549
EP - 553
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 4
ER -
