Role of the parabrachial nuclei in the airway dilation evoked by the Hering-Breuer reflex

Ann M. Motekaitis; Irene C. Solomon; Marc P. Kaufman

doi:10.1016/0006-8993(94)01371-N

Role of the parabrachial nuclei in the airway dilation evoked by the Hering-Breuer reflex

Ann M. Motekaitis
, Irene C. Solomon
, Marc P. Kaufman

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

We tested the hypothesis that blockade of glutamatergic receptors in the parabrachial nucleus (PBN) of chloralose-anesthetized cats attenuated the reflex airway dilation evoked by activation of pulmonary stretch receptors. Unilateral microinjection of kynurenic acid (50 nl, 100 mM) into the PBN reversibly attenuated the reflex relaxation of the trachealis muscle in 7 cats. These findings suggest that the PBN is part of the central pathway mediating the airway dilation component of the Hering-Breuer reflex.

Original language	English (US)
Pages (from-to)	314-316
Number of pages	3
Journal	Brain research
Volume	671
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(94)01371-N
State	Published - Feb 13 1995

All Science Journal Classification (ASJC) codes

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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title = "Role of the parabrachial nuclei in the airway dilation evoked by the Hering-Breuer reflex",

abstract = "We tested the hypothesis that blockade of glutamatergic receptors in the parabrachial nucleus (PBN) of chloralose-anesthetized cats attenuated the reflex airway dilation evoked by activation of pulmonary stretch receptors. Unilateral microinjection of kynurenic acid (50 nl, 100 mM) into the PBN reversibly attenuated the reflex relaxation of the trachealis muscle in 7 cats. These findings suggest that the PBN is part of the central pathway mediating the airway dilation component of the Hering-Breuer reflex.",

author = "Motekaitis, \{Ann M.\} and Solomon, \{Irene C.\} and Kaufman, \{Marc P.\}",

note = "Funding Information: We thank Mr. Michael Wong for his technical assistance. This work was supported by NIH Grant HL40910.",

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doi = "10.1016/0006-8993(94)01371-N",

language = "English (US)",

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T1 - Role of the parabrachial nuclei in the airway dilation evoked by the Hering-Breuer reflex

AU - Motekaitis, Ann M.

AU - Solomon, Irene C.

AU - Kaufman, Marc P.

N1 - Funding Information: We thank Mr. Michael Wong for his technical assistance. This work was supported by NIH Grant HL40910.

PY - 1995/2/13

Y1 - 1995/2/13

N2 - We tested the hypothesis that blockade of glutamatergic receptors in the parabrachial nucleus (PBN) of chloralose-anesthetized cats attenuated the reflex airway dilation evoked by activation of pulmonary stretch receptors. Unilateral microinjection of kynurenic acid (50 nl, 100 mM) into the PBN reversibly attenuated the reflex relaxation of the trachealis muscle in 7 cats. These findings suggest that the PBN is part of the central pathway mediating the airway dilation component of the Hering-Breuer reflex.

AB - We tested the hypothesis that blockade of glutamatergic receptors in the parabrachial nucleus (PBN) of chloralose-anesthetized cats attenuated the reflex airway dilation evoked by activation of pulmonary stretch receptors. Unilateral microinjection of kynurenic acid (50 nl, 100 mM) into the PBN reversibly attenuated the reflex relaxation of the trachealis muscle in 7 cats. These findings suggest that the PBN is part of the central pathway mediating the airway dilation component of the Hering-Breuer reflex.

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JF - Brain research

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ER -

Role of the parabrachial nuclei in the airway dilation evoked by the Hering-Breuer reflex

Abstract

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