TY - JOUR
T1 - Roles of indole as an interspecies and interkingdom signaling molecule
AU - Lee, Jin Hyung
AU - Wood, Thomas K.
AU - Lee, Jintae
N1 - Funding Information:
This research was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (#2015R1A2A2A01004542 to J. Lee) and Basic Science Research Program through the NRF funded by the Ministry of Education (#215C000232 to J-H. Lee). T. K. Wood is supported by the Army Research Office (W911NF-14-1-0279).
Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2015
Y1 - 2015
N2 - A number of bacteria, and some plants, produce large quantities of indole, which is widespread in animal intestinal tracts and in the rhizosphere. Indole, as an interspecies and interkingdom signaling molecule, plays important roles in bacterial pathogenesis and eukaryotic immunity. Furthermore, indole and its derivatives are viewed as potential antivirulence compounds against antibiotic-resistant pathogens because of their ability to inhibit quorum sensing and virulence factor production. Indole modulates oxidative stress, intestinal inflammation, and hormone secretion in animals, and it controls plant defense systems and growth. Insects and nematodes can recognize indole, which controls some of their behavior. This review presents current knowledge regarding indole and its derivatives, their biotechnological applications and their role in prokaryotic and eukaryotic systems.
AB - A number of bacteria, and some plants, produce large quantities of indole, which is widespread in animal intestinal tracts and in the rhizosphere. Indole, as an interspecies and interkingdom signaling molecule, plays important roles in bacterial pathogenesis and eukaryotic immunity. Furthermore, indole and its derivatives are viewed as potential antivirulence compounds against antibiotic-resistant pathogens because of their ability to inhibit quorum sensing and virulence factor production. Indole modulates oxidative stress, intestinal inflammation, and hormone secretion in animals, and it controls plant defense systems and growth. Insects and nematodes can recognize indole, which controls some of their behavior. This review presents current knowledge regarding indole and its derivatives, their biotechnological applications and their role in prokaryotic and eukaryotic systems.
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U2 - 10.1016/j.tim.2015.08.001
DO - 10.1016/j.tim.2015.08.001
M3 - Review article
C2 - 26439294
AN - SCOPUS:84960354427
SN - 0966-842X
VL - 23
SP - 707
EP - 718
JO - Trends in Microbiology
JF - Trends in Microbiology
IS - 11
ER -
