Roles of IRF4 in various immune cells in systemic lupus erythematosus

Ze Xiu Xiao; Rongzhen Liang; Nancy Olsen; Song Guo Zheng

doi:10.1016/j.intimp.2024.112077

Roles of IRF4 in various immune cells in systemic lupus erythematosus

Ze Xiu Xiao, Rongzhen Liang, Nancy Olsen, Song Guo Zheng

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Interferon regulatory factor 4 (IRF4) is a member of IRF family of transcription factors which mainly regulates the transcription of IFN. IRF4 is restrictively expressed in immune cells such as T and B cells, macrophages, as well as DC. It is essential for the development and function of these cells. Since these cells take part in the homeostasis of the immune system and dysfunction of them contributes to the initiation and progress of systemic lupus erythematosus (SLE), the roles of IRF4 in the SLE development becomes an important topic. Here we systemically discuss the biological characteristics of IRF4 in various immune cells and analyze the pathologic effects of IRF4 alteration in SLE and the potential targeting therapeutics of SLE.

Original language	English (US)
Article number	112077
Journal	International Immunopharmacology
Volume	133
DOIs	https://doi.org/10.1016/j.intimp.2024.112077
State	Published - May 30 2024

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Pharmacology

Access to Document

10.1016/j.intimp.2024.112077

Cite this

@article{788e7c69b94b4cff9633848f3c225334,

title = "Roles of IRF4 in various immune cells in systemic lupus erythematosus",

abstract = "Interferon regulatory factor 4 (IRF4) is a member of IRF family of transcription factors which mainly regulates the transcription of IFN. IRF4 is restrictively expressed in immune cells such as T and B cells, macrophages, as well as DC. It is essential for the development and function of these cells. Since these cells take part in the homeostasis of the immune system and dysfunction of them contributes to the initiation and progress of systemic lupus erythematosus (SLE), the roles of IRF4 in the SLE development becomes an important topic. Here we systemically discuss the biological characteristics of IRF4 in various immune cells and analyze the pathologic effects of IRF4 alteration in SLE and the potential targeting therapeutics of SLE.",

author = "Xiao, {Ze Xiu} and Rongzhen Liang and Nancy Olsen and Zheng, {Song Guo}",

note = "Publisher Copyright: {\textcopyright} 2024 Elsevier B.V.",

year = "2024",

month = may,

day = "30",

doi = "10.1016/j.intimp.2024.112077",

language = "English (US)",

volume = "133",

journal = "International Immunopharmacology",

issn = "1567-5769",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Roles of IRF4 in various immune cells in systemic lupus erythematosus

AU - Xiao, Ze Xiu

AU - Liang, Rongzhen

AU - Olsen, Nancy

AU - Zheng, Song Guo

PY - 2024/5/30

Y1 - 2024/5/30

N2 - Interferon regulatory factor 4 (IRF4) is a member of IRF family of transcription factors which mainly regulates the transcription of IFN. IRF4 is restrictively expressed in immune cells such as T and B cells, macrophages, as well as DC. It is essential for the development and function of these cells. Since these cells take part in the homeostasis of the immune system and dysfunction of them contributes to the initiation and progress of systemic lupus erythematosus (SLE), the roles of IRF4 in the SLE development becomes an important topic. Here we systemically discuss the biological characteristics of IRF4 in various immune cells and analyze the pathologic effects of IRF4 alteration in SLE and the potential targeting therapeutics of SLE.

AB - Interferon regulatory factor 4 (IRF4) is a member of IRF family of transcription factors which mainly regulates the transcription of IFN. IRF4 is restrictively expressed in immune cells such as T and B cells, macrophages, as well as DC. It is essential for the development and function of these cells. Since these cells take part in the homeostasis of the immune system and dysfunction of them contributes to the initiation and progress of systemic lupus erythematosus (SLE), the roles of IRF4 in the SLE development becomes an important topic. Here we systemically discuss the biological characteristics of IRF4 in various immune cells and analyze the pathologic effects of IRF4 alteration in SLE and the potential targeting therapeutics of SLE.

UR - http://www.scopus.com/inward/record.url?scp=85190254219&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85190254219&partnerID=8YFLogxK

U2 - 10.1016/j.intimp.2024.112077

DO - 10.1016/j.intimp.2024.112077

M3 - Review article

C2 - 38615379

AN - SCOPUS:85190254219

SN - 1567-5769

VL - 133

JO - International Immunopharmacology

JF - International Immunopharmacology

M1 - 112077

ER -

Roles of IRF4 in various immune cells in systemic lupus erythematosus

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this