TY - JOUR
T1 - Romantic Partner Alcohol Misuse Interacts With GABRA2 Genotype to Predict Frequency of Drunkenness in Young Adulthood
AU - Gajos, Jamie M.
AU - Russell, Michael A.
AU - Cleveland, H. Harrington
AU - Vandenbergh, David J.
AU - Feinberg, Mark E.
N1 - Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was supported by the Prevention and Methodology Training Program (T32 DA017629, PI: L. M. Collins; P50 DA039838 PI: L. M. Collins). PROSPER and gPROSPER projects were supported by Grants DA013709 (PI: Spoth) and DA030389 (M-PIs: Cleveland and Vandenbergh) from the National Institute on Drug Abuse, respectively. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute on Drug Abuse or the National Institutes of Health.
Publisher Copyright:
© The Author(s) 2018.
PY - 2019/2/1
Y1 - 2019/2/1
N2 - Previous research has identified the importance of romantic partners—including spouses, significant others, and dating partners—for influencing the engagement in health-risking behaviors, such as alcohol misuse during emerging adulthood. Although genetic factors are known to play a role in the development of young adult alcohol misuse, little research has examined whether genetic factors affect young adults’ susceptibility to their romantic partners’ alcohol misusing behaviors. The current study tests whether a single nucleotide polymorphism in the GABRA2 gene (rs279845) moderates the relationship between romantic partner alcohol misuse and frequency of drunkenness in young adulthood. Results revealed differential risk associated with romantic partner alcohol misuse and young adult drunk behavior according to GABRA2 genotype, such that individuals with the TT genotype displayed an elevated risk for frequency of drunkenness when romantic partner alcohol misuse was also high (incidence rate ratio = 1.06, p ⩽.05). The findings demonstrate the potential for genetic factors to moderate the influence of romantic partners’ alcohol misuse on drunk behavior during the transition to young adulthood.
AB - Previous research has identified the importance of romantic partners—including spouses, significant others, and dating partners—for influencing the engagement in health-risking behaviors, such as alcohol misuse during emerging adulthood. Although genetic factors are known to play a role in the development of young adult alcohol misuse, little research has examined whether genetic factors affect young adults’ susceptibility to their romantic partners’ alcohol misusing behaviors. The current study tests whether a single nucleotide polymorphism in the GABRA2 gene (rs279845) moderates the relationship between romantic partner alcohol misuse and frequency of drunkenness in young adulthood. Results revealed differential risk associated with romantic partner alcohol misuse and young adult drunk behavior according to GABRA2 genotype, such that individuals with the TT genotype displayed an elevated risk for frequency of drunkenness when romantic partner alcohol misuse was also high (incidence rate ratio = 1.06, p ⩽.05). The findings demonstrate the potential for genetic factors to moderate the influence of romantic partners’ alcohol misuse on drunk behavior during the transition to young adulthood.
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U2 - 10.1177/1043986218810578
DO - 10.1177/1043986218810578
M3 - Article
C2 - 31598057
AN - SCOPUS:85058470371
SN - 1043-9862
VL - 35
SP - 7
EP - 20
JO - Journal of Contemporary Criminal Justice
JF - Journal of Contemporary Criminal Justice
IS - 1
ER -