Run-up and run-down

Nicholas Graziane; Yan Dong

doi:10.1007/978-1-4939-3274-0_16

Run-up and run-down

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

A burden associated with electrophysiology is potential artifacts that look like physiological events, but are instead mistakenly incorporated into the experimental recordings. Two such artifacts discussed in this chapter are current run-up and current run-down. Simply put, baseline responses increase (run-up) or decrease (run-down) over time. Membrane channels recorded using cell-attached, whole-cell, and excised- patch configurations are all susceptible to run-up/run-down. The purpose of this chapter is to discuss empirically derived causes of run-up and run-down so that both errors can be either identified or avoided before or during current measurements. Unfortunately, data showing causes and solutions to run-up and run-down in all membrane channels does not exist. However, we discuss receptors and cell types that have been studied for the purpose of keeping the experimenter aware of problem solving strategies during electrophysiological measurements.

Original language	English (US)
Title of host publication	Neuromethods
Publisher	Humana Press Inc.
Pages	187-192
Number of pages	6
DOIs	https://doi.org/10.1007/978-1-4939-3274-0_16
State	Published - Oct 1 2016

Publication series

Name	Neuromethods
Volume	112
ISSN (Print)	0893-2336
ISSN (Electronic)	1940-6045

All Science Journal Classification (ASJC) codes

Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)
Psychiatry and Mental health

Access to Document

10.1007/978-1-4939-3274-0_16

Cite this

@inbook{3dad0be9884840be9d57e2819410e059,

title = "Run-up and run-down",

abstract = "A burden associated with electrophysiology is potential artifacts that look like physiological events, but are instead mistakenly incorporated into the experimental recordings. Two such artifacts discussed in this chapter are current run-up and current run-down. Simply put, baseline responses increase (run-up) or decrease (run-down) over time. Membrane channels recorded using cell-attached, whole-cell, and excised- patch configurations are all susceptible to run-up/run-down. The purpose of this chapter is to discuss empirically derived causes of run-up and run-down so that both errors can be either identified or avoided before or during current measurements. Unfortunately, data showing causes and solutions to run-up and run-down in all membrane channels does not exist. However, we discuss receptors and cell types that have been studied for the purpose of keeping the experimenter aware of problem solving strategies during electrophysiological measurements.",

author = "Nicholas Graziane and Yan Dong",

note = "Publisher Copyright: {\textcopyright} 2016 Springer Science+Business Media New York",

year = "2016",

month = oct,

day = "1",

doi = "10.1007/978-1-4939-3274-0_16",

language = "English (US)",

series = "Neuromethods",

publisher = "Humana Press Inc.",

pages = "187--192",

booktitle = "Neuromethods",

}

TY - CHAP

T1 - Run-up and run-down

AU - Graziane, Nicholas

AU - Dong, Yan

PY - 2016/10/1

Y1 - 2016/10/1

N2 - A burden associated with electrophysiology is potential artifacts that look like physiological events, but are instead mistakenly incorporated into the experimental recordings. Two such artifacts discussed in this chapter are current run-up and current run-down. Simply put, baseline responses increase (run-up) or decrease (run-down) over time. Membrane channels recorded using cell-attached, whole-cell, and excised- patch configurations are all susceptible to run-up/run-down. The purpose of this chapter is to discuss empirically derived causes of run-up and run-down so that both errors can be either identified or avoided before or during current measurements. Unfortunately, data showing causes and solutions to run-up and run-down in all membrane channels does not exist. However, we discuss receptors and cell types that have been studied for the purpose of keeping the experimenter aware of problem solving strategies during electrophysiological measurements.

AB - A burden associated with electrophysiology is potential artifacts that look like physiological events, but are instead mistakenly incorporated into the experimental recordings. Two such artifacts discussed in this chapter are current run-up and current run-down. Simply put, baseline responses increase (run-up) or decrease (run-down) over time. Membrane channels recorded using cell-attached, whole-cell, and excised- patch configurations are all susceptible to run-up/run-down. The purpose of this chapter is to discuss empirically derived causes of run-up and run-down so that both errors can be either identified or avoided before or during current measurements. Unfortunately, data showing causes and solutions to run-up and run-down in all membrane channels does not exist. However, we discuss receptors and cell types that have been studied for the purpose of keeping the experimenter aware of problem solving strategies during electrophysiological measurements.

UR - http://www.scopus.com/inward/record.url?scp=84950342011&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84950342011&partnerID=8YFLogxK

U2 - 10.1007/978-1-4939-3274-0_16

DO - 10.1007/978-1-4939-3274-0_16

M3 - Chapter

AN - SCOPUS:84950342011

T3 - Neuromethods

SP - 187

EP - 192

BT - Neuromethods

PB - Humana Press Inc.

ER -

Run-up and run-down

Abstract

Publication series

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this