Safety Assessment of Alkyl Ethylhexanoates as Used in Cosmetics

Monice Fiume; B. A.R.T. Heldreth; Wilma F. Bergfeld; Donald V. Belsito; Ronald A. Hill; Curtis D. Klaassen; Daniel C. Liebler; James G. Marks; Ronald C. Shank; Thomas J. Slaga; Paul W. Snyder; F. Alan Andersen; Lillian J. Gill

doi:10.1177/1091581815617794

Safety Assessment of Alkyl Ethylhexanoates as Used in Cosmetics

Monice Fiume, B. A.R.T. Heldreth, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, F. Alan Andersen, Lillian J. Gill

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) assessed the safety of 16 alkyl ethylhexanoates for use in cosmetics, concluding that these ingredients are safe in cosmetic formulations in the present practices of use and concentrations when formulated to be nonirritating. The alkyl ethylhexanoates primarily function as skin-conditioning agents in cosmetics. The highest concentration of use reported for any of the alkyl ethylhexanoates is 77.3% cetyl ethylhexanoate in rinse-off formulations used near the eye, and the highest leave-on use reported is 52% cetyl ethylhexanoate in lipstick formulations. The Panel reviewed available animal and clinical data related to these ingredients, and the similarities in structure, properties, functions, and uses of ingredients from previous CIR assessments on constituent alcohols that allowed for extrapolation of the available toxicological data to assess the safety of the entire group.

Original language	English (US)
Pages (from-to)	61S-73S
Journal	International journal of toxicology
Volume	34
DOIs	https://doi.org/10.1177/1091581815617794
State	Published - Nov 1 2015

All Science Journal Classification (ASJC) codes

Toxicology

Access to Document

10.1177/1091581815617794

Cite this

@article{8a06a418fd3149db97270bd697ac9dd0,

title = "Safety Assessment of Alkyl Ethylhexanoates as Used in Cosmetics",

abstract = "The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) assessed the safety of 16 alkyl ethylhexanoates for use in cosmetics, concluding that these ingredients are safe in cosmetic formulations in the present practices of use and concentrations when formulated to be nonirritating. The alkyl ethylhexanoates primarily function as skin-conditioning agents in cosmetics. The highest concentration of use reported for any of the alkyl ethylhexanoates is 77.3% cetyl ethylhexanoate in rinse-off formulations used near the eye, and the highest leave-on use reported is 52% cetyl ethylhexanoate in lipstick formulations. The Panel reviewed available animal and clinical data related to these ingredients, and the similarities in structure, properties, functions, and uses of ingredients from previous CIR assessments on constituent alcohols that allowed for extrapolation of the available toxicological data to assess the safety of the entire group.",

author = "Monice Fiume and Heldreth, {B. A.R.T.} and Bergfeld, {Wilma F.} and Belsito, {Donald V.} and Hill, {Ronald A.} and Klaassen, {Curtis D.} and Liebler, {Daniel C.} and Marks, {James G.} and Shank, {Ronald C.} and Slaga, {Thomas J.} and Snyder, {Paul W.} and Andersen, {F. Alan} and Gill, {Lillian J.}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2015.",

year = "2015",

month = nov,

day = "1",

doi = "10.1177/1091581815617794",

language = "English (US)",

volume = "34",

pages = "61S--73S",

journal = "International journal of toxicology",

issn = "1091-5818",

publisher = "SAGE Publications Inc.",

}

TY - JOUR

T1 - Safety Assessment of Alkyl Ethylhexanoates as Used in Cosmetics

AU - Fiume, Monice

AU - Heldreth, B. A.R.T.

AU - Bergfeld, Wilma F.

AU - Belsito, Donald V.

AU - Hill, Ronald A.

AU - Klaassen, Curtis D.

AU - Liebler, Daniel C.

AU - Marks, James G.

AU - Shank, Ronald C.

AU - Slaga, Thomas J.

AU - Snyder, Paul W.

AU - Andersen, F. Alan

AU - Gill, Lillian J.

PY - 2015/11/1

Y1 - 2015/11/1

N2 - The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) assessed the safety of 16 alkyl ethylhexanoates for use in cosmetics, concluding that these ingredients are safe in cosmetic formulations in the present practices of use and concentrations when formulated to be nonirritating. The alkyl ethylhexanoates primarily function as skin-conditioning agents in cosmetics. The highest concentration of use reported for any of the alkyl ethylhexanoates is 77.3% cetyl ethylhexanoate in rinse-off formulations used near the eye, and the highest leave-on use reported is 52% cetyl ethylhexanoate in lipstick formulations. The Panel reviewed available animal and clinical data related to these ingredients, and the similarities in structure, properties, functions, and uses of ingredients from previous CIR assessments on constituent alcohols that allowed for extrapolation of the available toxicological data to assess the safety of the entire group.

AB - The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) assessed the safety of 16 alkyl ethylhexanoates for use in cosmetics, concluding that these ingredients are safe in cosmetic formulations in the present practices of use and concentrations when formulated to be nonirritating. The alkyl ethylhexanoates primarily function as skin-conditioning agents in cosmetics. The highest concentration of use reported for any of the alkyl ethylhexanoates is 77.3% cetyl ethylhexanoate in rinse-off formulations used near the eye, and the highest leave-on use reported is 52% cetyl ethylhexanoate in lipstick formulations. The Panel reviewed available animal and clinical data related to these ingredients, and the similarities in structure, properties, functions, and uses of ingredients from previous CIR assessments on constituent alcohols that allowed for extrapolation of the available toxicological data to assess the safety of the entire group.

UR - http://www.scopus.com/inward/record.url?scp=84950317361&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84950317361&partnerID=8YFLogxK

U2 - 10.1177/1091581815617794

DO - 10.1177/1091581815617794

M3 - Review article

C2 - 26684798

AN - SCOPUS:84950317361

SN - 1091-5818

VL - 34

SP - 61S-73S

JO - International journal of toxicology

JF - International journal of toxicology

ER -

Safety Assessment of Alkyl Ethylhexanoates as Used in Cosmetics

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this