Safety Assessment of Amino Acid Alkyl Amides as Used in Cosmetics

Christina L. Burnett; Bart Heldreth; Wilma F. Bergfeld; Donald V. Belsito; Ronald A. Hill; Curtis D. Klaassen; Daniel C. Liebler; James G. Marks; Ronald C. Shank; Thomas J. Slaga; Paul W. Snyder; F. Alan Andersen; Lillian J. Gill

doi:10.1177/1091581816686048

Safety Assessment of Amino Acid Alkyl Amides as Used in Cosmetics

Christina L. Burnett, Bart Heldreth, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, F. Alan Andersen, Lillian J. Gill

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Abstract

The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the product use, formulation, and safety data of 115 amino acid alkyl amides, which function as skin and hair conditioning agents and as surfactants - cleansing agents in personal care products. Safety test data on dermal irritation and sensitization for the ingredients with the highest use concentrations, lauroyl lysine and sodium lauroyl glutamate, were reviewed and determined to adequately support the safe use of the ingredients in this report. The Panel concluded that amino acid alkyl amides are safe in the present practices of use and concentration in cosmetics, when formulated to be nonirritating.

Original language	English (US)
Pages (from-to)	17S-56S
Journal	International journal of toxicology
Volume	36
Issue number	1_suppl
DOIs	https://doi.org/10.1177/1091581816686048
State	Published - May 1 2017

All Science Journal Classification (ASJC) codes

Toxicology

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Burnett, C. L., Heldreth, B., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., Marks, J. G., Shank, R. C., Slaga, T. J., Snyder, P. W., Andersen, F. A., & Gill, L. J. (2017). Safety Assessment of Amino Acid Alkyl Amides as Used in Cosmetics. International journal of toxicology, 36(1_suppl), 17S-56S. https://doi.org/10.1177/1091581816686048

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title = "Safety Assessment of Amino Acid Alkyl Amides as Used in Cosmetics",

abstract = "The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the product use, formulation, and safety data of 115 amino acid alkyl amides, which function as skin and hair conditioning agents and as surfactants - cleansing agents in personal care products. Safety test data on dermal irritation and sensitization for the ingredients with the highest use concentrations, lauroyl lysine and sodium lauroyl glutamate, were reviewed and determined to adequately support the safe use of the ingredients in this report. The Panel concluded that amino acid alkyl amides are safe in the present practices of use and concentration in cosmetics, when formulated to be nonirritating.",

author = "Burnett, {Christina L.} and Bart Heldreth and Bergfeld, {Wilma F.} and Belsito, {Donald V.} and Hill, {Ronald A.} and Klaassen, {Curtis D.} and Liebler, {Daniel C.} and Marks, {James G.} and Shank, {Ronald C.} and Slaga, {Thomas J.} and Snyder, {Paul W.} and Andersen, {F. Alan} and Gill, {Lillian J.}",

note = "Publisher Copyright: {\textcopyright} American College of Toxicology.",

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doi = "10.1177/1091581816686048",

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AU - Burnett, Christina L.

AU - Heldreth, Bart

AU - Bergfeld, Wilma F.

AU - Belsito, Donald V.

AU - Hill, Ronald A.

AU - Klaassen, Curtis D.

AU - Liebler, Daniel C.

AU - Marks, James G.

AU - Shank, Ronald C.

AU - Slaga, Thomas J.

AU - Snyder, Paul W.

AU - Andersen, F. Alan

AU - Gill, Lillian J.

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AB - The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the product use, formulation, and safety data of 115 amino acid alkyl amides, which function as skin and hair conditioning agents and as surfactants - cleansing agents in personal care products. Safety test data on dermal irritation and sensitization for the ingredients with the highest use concentrations, lauroyl lysine and sodium lauroyl glutamate, were reviewed and determined to adequately support the safe use of the ingredients in this report. The Panel concluded that amino acid alkyl amides are safe in the present practices of use and concentration in cosmetics, when formulated to be nonirritating.

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Safety Assessment of Amino Acid Alkyl Amides as Used in Cosmetics

Abstract

All Science Journal Classification (ASJC) codes

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