@article{a4d83acef0914265a1743fa40cbac74e,
title = "Safety Assessment of Camellia sinensis–Derived Ingredients As Used in Cosmetics",
abstract = "Cosmetic ingredients derived from Camellia sinensis (tea) plant parts function as antioxidants and skin conditioning agents—humectant and miscellaneous. The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) reviewed relevant animal and human data related to these ingredients. The use of the leaf ingredients in beverages results in much larger systemic exposures than those possible from cosmetic use. Accordingly, concern over the systemic toxicity potential of leaf-derived ingredients is mitigated. Because product formulations may contain multiple botanical ingredients, each containing the same constituents of concern, formulators are advised to be aware of these constituents and to avoid reaching levels that may lead to sensitization or other toxic effects. The Panel concluded that the C sinensis leaf-derived ingredients are safe in the present practices of use and concentration described in this safety assessment when formulated to be nonsensitizing. However, the available data are insufficient to determine whether the non-leaf-derived ingredients are safe for use in cosmetics.",
author = "Becker, {Lillian C.} and Bergfeld, {Wilma F.} and Belsito, {Donald V.} and Hill, {Ronald A.} and Klaassen, {Curtis D.} and Liebler, {Daniel C.} and Marks, {James G.} and Shank, {Ronald C.} and Slaga, {Thomas J.} and Snyder, {Paul W.} and Gill, {Lillian J.} and Bart Heldreth",
note = "Funding Information: Camellia sinensis– Derived Ingredients As Used in Cosmetics Becker Lillian C. 1 Bergfeld Wilma F. 2 Belsito Donald V. 2 Hill Ronald A. 2 Klaassen Curtis D. 2 Liebler Daniel C. 2 Marks James G. Jr 2 Shank Ronald C. 2 Slaga Thomas J. 2 Snyder Paul W. 2 Gill Lillian J. 3 Heldreth Bart 4 1 Cosmetic Ingredient Review Former Scientific Analyst/Writer, Cosmetic Ingredient Review, Washington, DC, USA 2 Cosmetic Ingredient Review Expert Panel Member, Cosmetic Ingredient Review, Washington, DC, USA 3 Cosmetic Ingredient Review Former Director, Cosmetic Ingredient Review, Washington, DC, USA 4 Cosmetic Ingredient Review Executive Director, Cosmetic Ingredient Review, Washington, DC, USA Bart Heldreth, Executive Director, Cosmetic Ingredient Review, 1620 L Street, NW, Suite 1200, Washington, DC 20036, USA. Email: cirinfo@cir-safety.org 11 2019 38 3_suppl 48S 70S {\textcopyright} The Author(s) 2019 2019 American College of Toxicology Cosmetic ingredients derived from Camellia sinensis (tea) plant parts function as antioxidants and skin conditioning agents—humectant and miscellaneous. The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) reviewed relevant animal and human data related to these ingredients. The use of the leaf ingredients in beverages results in much larger systemic exposures than those possible from cosmetic use. Accordingly, concern over the systemic toxicity potential of leaf-derived ingredients is mitigated. Because product formulations may contain multiple botanical ingredients, each containing the same constituents of concern, formulators are advised to be aware of these constituents and to avoid reaching levels that may lead to sensitization or other toxic effects. The Panel concluded that the C sinensis leaf-derived ingredients are safe in the present practices of use and concentration described in this safety assessment when formulated to be nonsensitizing. However, the available data are insufficient to determine whether the non-leaf-derived ingredients are safe for use in cosmetics. cosmetics safety Camellia sinensis cover-date November/December 2019 typesetter ts3 Authors{\textquoteright} Note Unpublished sources cited in this report are available from the Executive Director, Cosmetic Ingredient Review, 1620 L Street, NW, Suite 1200, Washington, DC 20036, USA. Author Contributions L. Becker contributed to conception and design, contributed to acquisition, analysis, and interpretation, drafted the manuscript, and critically revised the manuscript. W. Bergfeld, D. Belsito, R. Hill, C. Klaassen, D. Liebler, J. Marks, R. Shank, T. Slaga, P. Snyder, and L. Gill contributed to conception and design, contributed to analysis and interpretation, and critically revised the manuscript. B. Heldreth contributed to analysis and interpretation and critically revised the manuscript. All authors gave final approval and agree to be accountable for all aspects of work ensuring integrity and accuracy. Declaration of Conflicting Interests The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Funding The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The articles in this supplement were sponsored by the Cosmetic Ingredient Review. The Cosmetic Ingredient Review is financially supported by the Personal Care Products Council. Publisher Copyright: {\textcopyright} The Author(s) 2019.",
year = "2019",
month = nov,
day = "1",
doi = "10.1177/1091581819889914",
language = "English (US)",
volume = "38",
pages = "48S--70S",
journal = "International journal of toxicology",
issn = "1091-5818",
publisher = "SAGE Publications Inc.",
number = "3_suppl",
}