Safety Assessment of Caprylhydroxamic Acid as Used in Cosmetics

Monice M. Fiume; Wilma F. Bergfeld; Donald V. Belsito; Ronald A. Hill; Curtis D. Klaassen; Daniel C. Liebler; James G. Marks; Lisa A. Peterson; Ronald C. Shank; Thomas J. Slaga; Paul W. Snyder; Bart Heldreth

doi:10.1177/10915818251343874

Safety Assessment of Caprylhydroxamic Acid as Used in Cosmetics

Monice M. Fiume
, Wilma F. Bergfeld
, Donald V. Belsito
, Ronald A. Hill
, Curtis D. Klaassen
, Daniel C. Liebler
, James G. Marks
, Lisa A. Peterson
, Ronald C. Shank
, Thomas J. Slaga
, Paul W. Snyder
, Bart Heldreth

Research output: Contribution to journal › Article › peer-review

Abstract

The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of Caprylhydroxamic Acid as used in cosmetic formulations; this ingredient is reported to function as a chelating agent. Positive sensitization results that occurred with the use of a moisturizer containing Caprylhydroxamic Acid appeared to correlate with use on damaged skin. Therefore, the Panel cautioned against the use of Caprylhydroxamic Acid in a manner that would result in increased penetration. A quantitative risk assessment (QRA) was performed, using a weight-of-evidence no-expected-sensitization-induction-level (WoE NESIL) of 1056 μg/cm². The Panel concluded that Caprylhydroxamic Acid is safe in cosmetics in the present practices of use and concentration described in this safety assessment.

Original language	English (US)
Pages (from-to)	103S-123S
Journal	International Journal of Toxicology
Volume	44
Issue number	2
DOIs	https://doi.org/10.1177/10915818251343874
State	Published - Aug 2025

All Science Journal Classification (ASJC) codes

Toxicology

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10.1177/10915818251343874

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@article{f50781e9df254cc39078c9e6a05c77df,

title = "Safety Assessment of Caprylhydroxamic Acid as Used in Cosmetics",

abstract = "The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of Caprylhydroxamic Acid as used in cosmetic formulations; this ingredient is reported to function as a chelating agent. Positive sensitization results that occurred with the use of a moisturizer containing Caprylhydroxamic Acid appeared to correlate with use on damaged skin. Therefore, the Panel cautioned against the use of Caprylhydroxamic Acid in a manner that would result in increased penetration. A quantitative risk assessment (QRA) was performed, using a weight-of-evidence no-expected-sensitization-induction-level (WoE NESIL) of 1056 μg/cm2. The Panel concluded that Caprylhydroxamic Acid is safe in cosmetics in the present practices of use and concentration described in this safety assessment.",

author = "Fiume, \{Monice M.\} and Bergfeld, \{Wilma F.\} and Belsito, \{Donald V.\} and Hill, \{Ronald A.\} and Klaassen, \{Curtis D.\} and Liebler, \{Daniel C.\} and Marks, \{James G.\} and Peterson, \{Lisa A.\} and Shank, \{Ronald C.\} and Slaga, \{Thomas J.\} and Snyder, \{Paul W.\} and Bart Heldreth",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2025",

year = "2025",

month = aug,

doi = "10.1177/10915818251343874",

language = "English (US)",

volume = "44",

pages = "103S--123S",

journal = "International Journal of Toxicology",

issn = "1091-5818",

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T1 - Safety Assessment of Caprylhydroxamic Acid as Used in Cosmetics

AU - Fiume, Monice M.

AU - Bergfeld, Wilma F.

AU - Belsito, Donald V.

AU - Hill, Ronald A.

AU - Klaassen, Curtis D.

AU - Liebler, Daniel C.

AU - Marks, James G.

AU - Peterson, Lisa A.

AU - Shank, Ronald C.

AU - Slaga, Thomas J.

AU - Snyder, Paul W.

AU - Heldreth, Bart

PY - 2025/8

Y1 - 2025/8

N2 - The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of Caprylhydroxamic Acid as used in cosmetic formulations; this ingredient is reported to function as a chelating agent. Positive sensitization results that occurred with the use of a moisturizer containing Caprylhydroxamic Acid appeared to correlate with use on damaged skin. Therefore, the Panel cautioned against the use of Caprylhydroxamic Acid in a manner that would result in increased penetration. A quantitative risk assessment (QRA) was performed, using a weight-of-evidence no-expected-sensitization-induction-level (WoE NESIL) of 1056 μg/cm2. The Panel concluded that Caprylhydroxamic Acid is safe in cosmetics in the present practices of use and concentration described in this safety assessment.

AB - The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of Caprylhydroxamic Acid as used in cosmetic formulations; this ingredient is reported to function as a chelating agent. Positive sensitization results that occurred with the use of a moisturizer containing Caprylhydroxamic Acid appeared to correlate with use on damaged skin. Therefore, the Panel cautioned against the use of Caprylhydroxamic Acid in a manner that would result in increased penetration. A quantitative risk assessment (QRA) was performed, using a weight-of-evidence no-expected-sensitization-induction-level (WoE NESIL) of 1056 μg/cm2. The Panel concluded that Caprylhydroxamic Acid is safe in cosmetics in the present practices of use and concentration described in this safety assessment.

UR - https://www.scopus.com/pages/publications/105011883423

UR - https://www.scopus.com/pages/publications/105011883423#tab=citedBy

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SN - 1091-5818

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JO - International Journal of Toxicology

JF - International Journal of Toxicology

IS - 2

ER -

Safety Assessment of Caprylhydroxamic Acid as Used in Cosmetics

Abstract

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