Safety Assessment of Decyl Glucoside and Other Alkyl Glucosides as Used in Cosmetics

Monice M. Fiume; Bart Heldreth; Wilma F. Bergfeld; Donald V. Belsito; Ronald A. Hill; Curtis D. Klaassen; Daniel Liebler; James G. Marks; Ronald C. Shank; Thomas J. Slaga; Paul W. Snyder; F. Alan Andersen

doi:10.1177/1091581813497764

Safety Assessment of Decyl Glucoside and Other Alkyl Glucosides as Used in Cosmetics

Monice M. Fiume, Bart Heldreth, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, F. Alan Andersen

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47 Scopus citations

Abstract

The Cosmetic Ingredient Review (CIR) Expert Panel assessed the safety of 19 alkyl glucosides as used in cosmetics and concluded that these ingredients are safe in the present practices of use and concentration when formulated to be nonirritating. Most of these ingredients function as surfactants in cosmetics, but some have additional functions as skin-conditioning agents, hair-conditioning agents, or emulsion stabilizers. The Panel reviewed the available animal and clinical data on these ingredients. Since glucoside hydrolases in human skin are likely to break down these ingredients to release their respective fatty acids and glucose, the Panel also reviewed CIR reports on the safety of fatty alcohols and were able to extrapolate data from those previous reports to support safety.

Original language	English (US)
Pages (from-to)	22S-48S
Journal	International journal of toxicology
Volume	32
DOIs	https://doi.org/10.1177/1091581813497764
State	Published - Sep 2013

All Science Journal Classification (ASJC) codes

Toxicology

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10.1177/1091581813497764

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title = "Safety Assessment of Decyl Glucoside and Other Alkyl Glucosides as Used in Cosmetics",

abstract = "The Cosmetic Ingredient Review (CIR) Expert Panel assessed the safety of 19 alkyl glucosides as used in cosmetics and concluded that these ingredients are safe in the present practices of use and concentration when formulated to be nonirritating. Most of these ingredients function as surfactants in cosmetics, but some have additional functions as skin-conditioning agents, hair-conditioning agents, or emulsion stabilizers. The Panel reviewed the available animal and clinical data on these ingredients. Since glucoside hydrolases in human skin are likely to break down these ingredients to release their respective fatty acids and glucose, the Panel also reviewed CIR reports on the safety of fatty alcohols and were able to extrapolate data from those previous reports to support safety.",

author = "Fiume, {Monice M.} and Bart Heldreth and Bergfeld, {Wilma F.} and Belsito, {Donald V.} and Hill, {Ronald A.} and Klaassen, {Curtis D.} and Daniel Liebler and Marks, {James G.} and Shank, {Ronald C.} and Slaga, {Thomas J.} and Snyder, {Paul W.} and Andersen, {F. Alan}",

note = "Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The articles in this supplement were sponsored by the Cosmetic Ingredient Review. The Cosmetic Ingredient Review is financially supported by the Personal Care Products Council.",

year = "2013",

month = sep,

doi = "10.1177/1091581813497764",

language = "English (US)",

volume = "32",

pages = "22S--48S",

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AU - Fiume, Monice M.

AU - Heldreth, Bart

AU - Bergfeld, Wilma F.

AU - Belsito, Donald V.

AU - Hill, Ronald A.

AU - Klaassen, Curtis D.

AU - Liebler, Daniel

AU - Marks, James G.

AU - Shank, Ronald C.

AU - Slaga, Thomas J.

AU - Snyder, Paul W.

AU - Andersen, F. Alan

N1 - Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The articles in this supplement were sponsored by the Cosmetic Ingredient Review. The Cosmetic Ingredient Review is financially supported by the Personal Care Products Council.

PY - 2013/9

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AB - The Cosmetic Ingredient Review (CIR) Expert Panel assessed the safety of 19 alkyl glucosides as used in cosmetics and concluded that these ingredients are safe in the present practices of use and concentration when formulated to be nonirritating. Most of these ingredients function as surfactants in cosmetics, but some have additional functions as skin-conditioning agents, hair-conditioning agents, or emulsion stabilizers. The Panel reviewed the available animal and clinical data on these ingredients. Since glucoside hydrolases in human skin are likely to break down these ingredients to release their respective fatty acids and glucose, the Panel also reviewed CIR reports on the safety of fatty alcohols and were able to extrapolate data from those previous reports to support safety.

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Safety Assessment of Decyl Glucoside and Other Alkyl Glucosides as Used in Cosmetics

Abstract

All Science Journal Classification (ASJC) codes

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